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Título: | Mechanisms of P/CAF auto-acetylation |
Autor: | Santos Rosa, Helena; Kouzarides, Tony; Martínez-Balbás, Marian CSIC ORCID | Fecha de publicación: | 1-ago-2003 | Editor: | Oxford University Press | Citación: | Nucleic Acids Research 31(15): 4285–4292 (2003) | Resumen: | P/CAF is a histone acetyltransferase enzyme which was originally identified as a CBP/p300-binding protein. In this manuscript we report that human P/CAF is acetylated in vivo. We find that P/CAF is acetylated by itself and by p300 but not by CBP. P/CAF acetylation can be an intra- or intermolecular event. The intermolecular acetylation requires the N-terminal domain of P/CAF. The intramolecular acetylation targets five lysines (416–442) at the P/CAF C-terminus, which are in the nuclear localisation signal (NLS). Finally, we show that acetylation of P/CAF leads to an increment of its histone acetyltransferase (HAT) activity. These findings identify a new post-translation modification on P/CAF which may regulate its function. | Descripción: | 8 pages, 7 figures.-- PMID: 12888487 [PubMed].-- PMCID: PMC169960. | Versión del editor: | http://dx.doi.org/10.1093/nar/gkg655 | URI: | http://hdl.handle.net/10261/29094 | DOI: | 10.1093/nar/gkg655 | ISSN: | 0305-1048 | E-ISSN: | 1362-4962 |
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