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Título: | Retinoic acid decreases thyroid hormone receptor expression in pituitary GH1 cells |
Autor: | Pérez, Paloma CSIC ORCID ; Sánchez-Pacheco, Aurora CSIC; Pascual, Ángel CSIC; Aranda, Ana CSIC ORCID | Fecha de publicación: | 1991 | Editor: | Elsevier | Citación: | Biochemical and Biophysical Research Communications 181: 9-15 (1991) | Resumen: | Retinoic acid produced a time and dose-dependent depletion of thyroid hormone receptors in GH1 cells without modifying their affinity for triiodothyronine (T3). A maximal decrease (50-70%) was obtained after 24-48 h incubation with 5-10 μM retinoic acid. Treatment with 0.8 nM T3 for 24 h caused a similar reduction and did not potentiate the decrease produced by these concentrations of retinoic acid. However, the combination of sub-maximally effective doses of both ligands had an additive effect on receptor levels. The reduction of receptor caused by retinoic acid is accompanied by a decreased expression of c-erbA α1 and α2 mRNAs, but the retinoid did not reduce the abundance of c-erbA β mRNA. In contrast, T3 decreased the levels of both α and β transcripts. | Versión del editor: | http://dx.doi.org/10.1016/S0006-291X(05)81374-9 | URI: | http://hdl.handle.net/10261/268260 | DOI: | 10.1016/S0006-291X(05)81374-9 | Identificadores: | doi: 10.1016/S0006-291X(05)81374-9 issn: 0006-291X |
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