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Título

Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes

AutorHaurum, Joseph S.; Arsequell, Gemma; Lellouch, Annemarie C.; Wong, Simon Y. C.; Dwek, Raymond A.
Palabras claveCytotoxic T cells (CTL)
Major Histocompatibility Complex (MHC)
Glycopeptides
Fecha de publicación1-ago-1994
EditorRockefeller University Press
CitaciónJournal of Experimental Science 180(2): 739–744 (1994)
ResumenCytotoxic T cells (CTL) recognize short peptide epitopes presented by class I glycoproteins encoded by the major histocompatibility complex (MHC). It is not yet known whether peptides containing posttranslationally modified amino acids can also be recognized by CTL. To address this issue, we have studied the immunogenicity and recognition of a glycopeptide carrying an O-linked N-acetylglucosamine (GlcNAc) monosaccharide-substituted serine residue. This posttranslational modification is catalyzed by a recently described cytosolic glycosyltransferase. We show that glycosylation does not affect peptide binding to MHC class I and that glycopeptides can elicit a strong CTL response that is glycopeptide specific. Furthermore, glycopeptide recognition by cytotoxic T cells is dependent on the chemical structure of the glycan as well as its position within the peptide.
Descripción6 pages, 5 figures.-- PMID: 8046349 [PubMed].-- PMCID: PMC2191607.
Versión del editorhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191607/
URIhttp://hdl.handle.net/10261/25148
ISSN0022-1007 (Print)
1540-9538 (Online)
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