Please use this identifier to cite or link to this item:
logo share SHARE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes

AuthorsHaurum, Joseph S.; Arsequell, Gemma CSIC ORCID; Lellouch, Annemarie C.; Wong, Simon Y. C.; Dwek, Raymond A.
KeywordsCytotoxic T cells (CTL)
Major Histocompatibility Complex (MHC)
Issue Date1-Aug-1994
PublisherRockefeller University Press
CitationJournal of Experimental Science 180(2): 739–744 (1994)
AbstractCytotoxic T cells (CTL) recognize short peptide epitopes presented by class I glycoproteins encoded by the major histocompatibility complex (MHC). It is not yet known whether peptides containing posttranslationally modified amino acids can also be recognized by CTL. To address this issue, we have studied the immunogenicity and recognition of a glycopeptide carrying an O-linked N-acetylglucosamine (GlcNAc) monosaccharide-substituted serine residue. This posttranslational modification is catalyzed by a recently described cytosolic glycosyltransferase. We show that glycosylation does not affect peptide binding to MHC class I and that glycopeptides can elicit a strong CTL response that is glycopeptide specific. Furthermore, glycopeptide recognition by cytotoxic T cells is dependent on the chemical structure of the glycan as well as its position within the peptide.
Description6 pages, 5 figures.-- PMID: 8046349 [PubMed].-- PMCID: PMC2191607.
Publisher version (URL)
Appears in Collections:(IQAC) Artículos

Files in This Item:
File Description SizeFormat
Haurum_John_et al.pdf592,33 kBAdobe PDFThumbnail
Show full item record
Review this work

Page view(s)

checked on Jul 5, 2022


checked on Jul 5, 2022

Google ScholarTM


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.