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| Título: | DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes |
Autor: | García-Ruiz, Beatriz; Castro de Moura, Manuel; Muntané, Gerard CSIC ORCID; Martorell, Lourdes; Bosch, Elena CSIC ORCID ; Esteller, Manel; Canales-Rodríguez, Erick Jorge; Pomarol-Clotet, Edith; Jiménez, Esther; Vieta, Eduard; Vilella, Elisabet | Palabras clave: | Bipolar disorder Discoidin domain receptor 1 Gene expression Human brain Methylation Myelin genes |
Fecha de publicación: | 4-may-2021 | Editor: | Future Medicine | Citación: | Epigenomics 13(11): (2021) | Resumen: | [Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. [Materials & methods] Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. [Results] DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. [Conclusion] DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination. |
Versión del editor: | https://doi.org/10.2217/epi-2021-0006 | URI: | http://hdl.handle.net/10261/250836 | DOI: | 10.2217/epi-2021-0006 | ISSN: | 1750-1911 | E-ISSN: | 1750-192X |
| Aparece en las colecciones: | (IBE) Artículos |
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