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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/250836
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dc.contributor.authorGarcía-Ruiz, Beatrizes_ES
dc.contributor.authorCastro de Moura, Manueles_ES
dc.contributor.authorMuntané, Gerardes_ES
dc.contributor.authorMartorell, Lourdeses_ES
dc.contributor.authorBosch, Elenaes_ES
dc.contributor.authorEsteller, Maneles_ES
dc.contributor.authorCanales-Rodríguez, Erick Jorgees_ES
dc.contributor.authorPomarol-Clotet, Edithes_ES
dc.contributor.authorJiménez, Estheres_ES
dc.contributor.authorVieta, Eduardes_ES
dc.contributor.authorVilella, Elisabetes_ES
dc.date.accessioned2021-09-23T11:19:27Z-
dc.date.available2021-09-23T11:19:27Z-
dc.date.issued2021-05-04-
dc.identifier.citationEpigenomics 13(11): (2021)es_ES
dc.identifier.issn1750-1911-
dc.identifier.urihttp://hdl.handle.net/10261/250836-
dc.description.abstract[Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes.es_ES
dc.description.abstract[Materials & methods] Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted.es_ES
dc.description.abstract[Results] DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes.es_ES
dc.description.abstract[Conclusion] DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.es_ES
dc.formatapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherFuture Medicinees_ES
dc.rightsclosedAccesses_ES
dc.subjectBipolar disorderes_ES
dc.subjectDiscoidin domain receptor 1es_ES
dc.subjectGene expressiones_ES
dc.subjectHuman braines_ES
dc.subjectMethylationes_ES
dc.subjectMyelin geneses_ES
dc.titleDDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin geneses_ES
dc.typeartículoes_ES
dc.identifier.doi10.2217/epi-2021-0006-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.2217/epi-2021-0006es_ES
dc.identifier.e-issn1750-192X-
dc.relation.csicSíes_ES
oprm.item.hasRevisionno ko 0 false*
dc.contributor.orcidGarcía- Ruiz, Beatriz [0000-0001-9552-949X]es_ES
dc.contributor.orcidCastro de Moura, Manuel [0000-0002-8488-5306]es_ES
dc.contributor.orcidMuntané, Gerard [0000-0003-1541-8365]es_ES
dc.contributor.orcidMartorell, Lourdes [0000-0003-4999-2197]es_ES
dc.contributor.orcidBosch, Elena [0000-0003-2848-103X]es_ES
dc.contributor.orcidEsteller, Manel [0000-0003-4490-6093]es_ES
dc.contributor.orcidCanales-Rodríguez, Erick Jorge [0000-0001-6421-2633]es_ES
dc.contributor.orcidPomarol-Clotet, Edith [0000-0002-8159-8563]es_ES
dc.contributor.orcidJiménez, Esther [0000-0001-6929-6207]es_ES
dc.contributor.orcidVieta, Eduard [0000-0002-0548-0053]es_ES
dc.contributor.orcidVilella, Elisabet [0000-0002-1887-5919]es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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