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Título: | SARS-CoV-2 RNA and antibody detection in breast milk from a prospective multicentre study in Spain |
Autor: | Bäuerl, Christine CSIC ORCID ; Randazzo, Walter CSIC ORCID; Sánchez Moragas, Gloria CSIC ORCID; Selma Royo, Marta; Garcia-Verdevio, Elia; Martínez-Rodríguez, Laura CSIC; Parra Llorca, Anna; Lerin, Carles; Fumadó, Victoria; Crovetto, Francesca; Crispi, Fátima; Pérez-Cano, Francisco J.; Rodríguez, Gerardo; Ruiz-Redondo, Gema; Campoy, Cristina; Martínez-Costa, Cecilia; Collado, María Carmen CSIC ORCID | Fecha de publicación: | 20-ago-2021 | Editor: | BMJ Publishing Group | Citación: | Archives of Disease in Childhood - Fetal and Neonatal Edition (2021) | Resumen: | Objectives To develop and validate a specific protocol for SARS-CoV-2 detection in breast milk matrix and to determine the impact of maternal SARS-CoV-2 infection on the presence, concentration and persistence of specific SARS-CoV-2 antibodies. Design and patients This is a prospective, multicentre longitudinal study (April–December 2020) in 60 mothers with SARS-CoV-2 infection and/or who have recovered from COVID-19. A control group of 13 women before the pandemic were also included. Setting Seven health centres from different provinces in Spain. Main outcome measures Presence of SARS-CoV-2 RNA in breast milk, targeting the N1 region of the nucleocapsid gene and the envelope (E) gene; presence and levels of SARS-CoV-2-specific immunoglobulins (Igs)—IgA, IgG and IgM—in breast milk samples from patients with COVID-19. Results All breast milk samples showed negative results for presence of SARS-CoV-2 RNA. We observed high intraindividual and interindividual variability in the antibody response to the receptor-binding domain of the SARS-CoV-2 spike protein for each of the three isotypes IgA, IgM and IgG. Main Protease (MPro) domain antibodies were also detected in milk. 82.9% (58 of 70) of milk samples were positive for at least one of the three antibody isotypes, with 52.9% of these positive for all three Igs. Positivity rate for IgA was relatively stable over time (65.2%–87.5%), whereas it raised continuously for IgG (from 47.8% for the first 10 days to 87.5% from day 41 up to day 206 post-PCR confirmation). Conclusions Our study confirms the safety of breast feeding and highlights the relevance of virus-specific SARS-CoV-2 antibody transfer. This study provides crucial data to support official breastfeeding recommendations based on scientific evidence. Trial registration number NCT04768244. | Versión del editor: | http://dx.doi.org/10.1136/archdischild-2021-322463 | URI: | http://hdl.handle.net/10261/250637 | DOI: | 10.1136/archdischild-2021-322463 | ISSN: | 1359-2998 | E-ISSN: | 1468-2052 |
Aparece en las colecciones: | (IATA) Artículos (PTI Salud Global) Colección Especial COVID-19 |
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