Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/245190
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Do, Thu Thi Anh | es_ES |
dc.contributor.author | Grijalvo, Santiago | es_ES |
dc.contributor.author | Imae, Toyoko | es_ES |
dc.contributor.author | García-Celma, M. J. | es_ES |
dc.contributor.author | Rodríguez-Abreu, Carlos | es_ES |
dc.date.accessioned | 2021-07-02T15:12:06Z | - |
dc.date.available | 2021-07-02T15:12:06Z | - |
dc.date.issued | 2021-10-15 | - |
dc.identifier.citation | Carbohydrate Polymers 270: 118366 (2021) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/245190 | - |
dc.description.abstract | Cellulose nanocrystals (CNCs) have advantages as drug delivery carriers because of their biocompatibility and the presence of hydroxyl groups which favor chemical modification and drug binding. The present study describes the development of novel multifunctional rod-like CNCs-based carriers as therapeutic platforms: CNCs were hybridized with folic acid for actively targeting tumor cells, carbon dots (Cdots) for both imaging and photodynamic/photothermal treatments and doxorubicin (DOX) as an anticancer drug. Hybridized carriers displayed excellent drug-loading capacity. Moreover, Cdots-containing hybrids showed fluorescence and photosensitized singlet oxygen generation and photothermal behavior. Carriers exhibited pH-sensitive drug release because of changing interactions with DOX, and this release proved to be effective against in vitro cervical cancer cells, as evidenced by dose-dependent reduced cellular viabilities. Additionally, DOX release was promoted by light irradiation and the photodynamic behavior by reactive oxygen species was confirmed. These results demonstrate the potential of multifunctional CNCs-based carriers as platforms for multimodal photodynamic/photothermal-chemotherapy. | es_ES |
dc.description.sponsorship | C.R. is grateful to the financial support from the Spanish Ministry of Economy and Competitiveness (CTQ2017-84998-P project), the European Regional Development Fund, Generalitat de Catalunya (2017SGR01778) and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN). Support from the I-LINK 1188 project (CSIC) is also acknowledged. T.T.A.D. thanks the National Taiwan University of Science and Technology for kind financial support through a student scholarship. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-84998-P/ES/SEGREGACION MOLECULAR A MULTIPLES ESCALAS EN SISTEMAS NO TENSIOCTIVOS PARA LA OBTENCION DE MATERIALES AVANZADOS/ | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Drug delivery system | es_ES |
dc.subject | Cellulose nanocrystals | es_ES |
dc.subject | Folic acid | es_ES |
dc.subject | Carbon dots | es_ES |
dc.subject | Doxorubicin | es_ES |
dc.subject | Photodynamic therapy | es_ES |
dc.title | A nanocellulose-based platform towards targeted chemo-photodynamic/photothermal cancer therapy | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.carbpol.2021.118366 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.carbpol.2021.118366 | es_ES |
dc.embargo.terms | 2022-10-15 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.contributor.orcid | Rodríguez-Abreu, Carlos [0000-0002-5917-6508] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (IQAC) Artículos (CIN2) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Carbohydrate polymers preproof.pdf | Artículo principal | 2,58 MB | Adobe PDF | Visualizar/Abrir |
1-s2.0-S0144861721007530-mmc1.docx | Material suplementario | 804,86 kB | Microsoft Word XML | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
28
checked on 12-may-2024
WEB OF SCIENCETM
Citations
23
checked on 29-feb-2024
Page view(s)
184
checked on 16-may-2024
Download(s)
203
checked on 16-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.