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Título: | Designing functionally versatile, highly immunogenic peptide-based multiepitopic vaccines against foot-and-mouth disease virus |
Autor: | Defaus, Sira; Rodríguez Pulido, Miguel Ramón CSIC ORCID; Sobrino Castelló, Francisco CSIC ORCID; Bustos, Maria José; León, Patricia de CSIC ORCID; Cañas-Arranz, Rodrigo; Forner, Mar; Blanco Lavilla, Esther CSIC ORCID; Andreu, David | Palabras clave: | Peptide-based vaccines Foot-and-mouth disease virus Multivalency Click chemistry Swine host |
Fecha de publicación: | 22-jul-2020 | Citación: | Vaccines 8 (2020) | Resumen: | A broadly protective and biosafe vaccine against foot-and-mouth disease virus (FMDV) remains an unmet need in the animal health sector. We have previously reported solid protection against serotype O FMDV a orded by dendrimeric peptide structures harboring virus-specific B- and T-cell epitopes, and also shown such type of multivalent presentations to be advantageous over simple B-T-epitope linear juxtaposition. Chemically, our vaccine platforms are modular constructions readily made from specified B- and T-cell epitope precursor peptides that are conjugated in solution. With the aim of developing an improved version of our formulations to be used for on-demand vaccine applications, we evaluate in this study a novel design for epitope presentation to the immune system based on a multiple antigen peptide (MAP) containing six immunologically relevant motifs arranged in dendrimeric fashion (named B2T-TB2). Interestingly, two B2T units fused tail-to-tail into a single homodimer platform elicited higher B- and T-cell specific responses than former candidates, with immunization scores remaining stable even after 4 months. Moreover, this macromolecular assembly shows consistent immune response in swine, the natural FMDV host, at reduced dose. Thus, our versatile, immunogenic prototype can find application in the development of peptide-based vaccine candidates for various therapeutic uses using safer and more ecacious vaccination regimens | Versión del editor: | http://dx.doi.org/10.3390/vaccines8030406 | URI: | http://hdl.handle.net/10261/235840 | DOI: | 10.3390/vaccines8030406 | Identificadores: | doi: 10.3390/vaccines8030406 issn: 2076-393X |
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