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http://hdl.handle.net/10261/235840
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Defaus, Sira | - |
dc.contributor.author | Rodríguez Pulido, Miguel Ramón | - |
dc.contributor.author | Sobrino Castelló, Francisco | - |
dc.contributor.author | Bustos, Maria José | - |
dc.contributor.author | León, Patricia de | - |
dc.contributor.author | Cañas-Arranz, Rodrigo | - |
dc.contributor.author | Forner, Mar | - |
dc.contributor.author | Blanco Lavilla, Esther | - |
dc.contributor.author | Andreu, David | - |
dc.date.accessioned | 2021-03-25T12:20:02Z | - |
dc.date.available | 2021-03-25T12:20:02Z | - |
dc.date.issued | 2020-07-22 | - |
dc.identifier | doi: 10.3390/vaccines8030406 | - |
dc.identifier | issn: 2076-393X | - |
dc.identifier.citation | Vaccines 8 (2020) | - |
dc.identifier.uri | http://hdl.handle.net/10261/235840 | - |
dc.description.abstract | A broadly protective and biosafe vaccine against foot-and-mouth disease virus (FMDV) remains an unmet need in the animal health sector. We have previously reported solid protection against serotype O FMDV a orded by dendrimeric peptide structures harboring virus-specific B- and T-cell epitopes, and also shown such type of multivalent presentations to be advantageous over simple B-T-epitope linear juxtaposition. Chemically, our vaccine platforms are modular constructions readily made from specified B- and T-cell epitope precursor peptides that are conjugated in solution. With the aim of developing an improved version of our formulations to be used for on-demand vaccine applications, we evaluate in this study a novel design for epitope presentation to the immune system based on a multiple antigen peptide (MAP) containing six immunologically relevant motifs arranged in dendrimeric fashion (named B2T-TB2). Interestingly, two B2T units fused tail-to-tail into a single homodimer platform elicited higher B- and T-cell specific responses than former candidates, with immunization scores remaining stable even after 4 months. Moreover, this macromolecular assembly shows consistent immune response in swine, the natural FMDV host, at reduced dose. Thus, our versatile, immunogenic prototype can find application in the development of peptide-based vaccine candidates for various therapeutic uses using safer and more ecacious vaccination regimens | - |
dc.description.sponsorship | Spanish Ministry of Science, Innovation and Universities grants AGL2014-48923-C2 and AGL2017-84097-C2-2-R (to D.A. and F.S.), and AGL2016-349 76445-R to E.B., as well as by Comunidad de Madrid co-financed ECFEDER funds (S2013/ABI-350 2906-PLATESA and P2018/BAA-4370 to F.S. and E.B.), and by Generalitat de Catalunya (2009SGR492 to D.A.). Work at Centro de Biología Molecular “Severo Ochoa” and at UPF was supported by Fundación Ramón Areces and by the Maria de Maeztu Program of the Spanish Ministry of Science, Innovation and Universities, | - |
dc.language | eng | - |
dc.rights | openAccess | - |
dc.subject | Peptide-based vaccines | - |
dc.subject | Foot-and-mouth disease virus | - |
dc.subject | Multivalency | - |
dc.subject | Click chemistry | - |
dc.subject | Swine host | - |
dc.title | Designing functionally versatile, highly immunogenic peptide-based multiepitopic vaccines against foot-and-mouth disease virus | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/vaccines8030406 | - |
dc.relation.publisherversion | http://dx.doi.org/10.3390/vaccines8030406 | - |
dc.date.updated | 2021-03-25T12:20:02Z | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Generalitat de Catalunya | - |
dc.contributor.funder | CSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM) | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.pmid | 32707834 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (CBM) Artículos |
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SobrinoF_DesigningFunctionally.pdf | 562,47 kB | Adobe PDF | Visualizar/Abrir |
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