English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/218932
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Encapsulation of water-soluble drugs in Poly (vinyl alcohol) (PVA)- microparticles via membrane emulsification: Influence of process and formulation parameters on structural and functional properties

AuthorsPiacentini. Emma; Bazzarelli, Fabio; Poerio, Teresa; Albisa, Airama; Irusta, Silvia; Mendoza, Gracia; Sebastian, Victor; Giorno, Lidietta
KeywordsMembrane emulsification
Encapsulation efficiency
Cell toxicity
Drug delivery
Issue Date2020
PublisherElsevier
CitationMaterials Today Communications 24: 100967 (2020)
AbstractDrug-loaded poly (vinyl alcohol) (PVA)-based microparticles have been synthetized by using membrane emulsification and chemical cross-linking. The encapsulation of two water-soluble molecules, catechol (CA) and diclofenac sodium (DS), has been considered as case studies. PVA hydrogels have been recognized as promising biomaterials and suitable candidates for drug delivery. However, the encapsulation of hydrophilic, low molecular weight drugs in particulate materials is currently an ambitious goal. The purpose of this work was to develop high-drug loading systems for hydrophilic molecule delivery based on uniformly distributed particulate carriers. Membrane emulsification has been used as advanced manufacturing method to design drug-loaded PVA microparticles with target properties in terms of particle size, particle size distribution, structure and functional activity. A special emphasis is laid on the important factors that contribute to tune the structured properties of microparticles, encapsulation efficiency/drug loading and drug delivery. In particular, the influence of emulsification method (membrane and homogenizing approaches), phase compositions (PVA concentration, drug concentration, physicochemical properties of drug), cross-linking reaction conditions (cross-linking agent concentration, acidic media) has been studied. Finally, the potential of PVA-based microparticles as drug delivery carriers as well as their in vitro cytotoxicity have been evaluated.
Publisher version (URL)https://doi.org/10.1016/j.mtcomm.2020.100967
URIhttp://hdl.handle.net/10261/218932
DOIhttp://dx.doi.org/10.1016/j.mtcomm.2020.100967
E-ISSN2352-4928
Appears in Collections:(ICMA) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.