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dc.contributor.author | Zhang, Songbai | - |
dc.contributor.author | Lloveras, Vega | - |
dc.contributor.author | Pulido, Daniel | - |
dc.contributor.author | Liko, Flonja | - |
dc.contributor.author | Pinto, Luiz Fernando | - |
dc.contributor.author | Albericio, Fernando | - |
dc.contributor.author | Royo, Miriam | - |
dc.contributor.author | Vidal Gancedo, José | - |
dc.date.accessioned | 2020-08-21T14:00:18Z | - |
dc.date.available | 2020-08-21T14:00:18Z | - |
dc.date.issued | 2020-08-14 | - |
dc.identifier.citation | Pharmaceutics 12(8): 772 (2020) | - |
dc.identifier.uri | http://hdl.handle.net/10261/218460 | - |
dc.description.abstract | Finding alternatives to gadolinium (Gd)-based contrast agents (CA) with the same or even better paramagnetic properties is crucial to overcome their established toxicity. Herein we describe the synthesis and characterization of entirely organic metal-free paramagnetic macromolecules based on biocompatible oligoethylene glycol dendrimers fully functionalized with 5 and 20 organic radicals (OEG Gn-PROXYL (n = 0, 1) radical dendrimers) with the aim to be used as magnetic resonance imaging (MRI) contrast agents. Conferring high water solubility on such systems is often a concern, especially in large generation dendrimers. Our approach to overcome such an issue in this study is by synthesizing dendrimers with highly water-soluble branches themselves. In this work, we show that the highly water-soluble OEG Gn-PROXYL (n = 0, 1) radical dendrimers obtained showed properties that convert them in good candidates to be studied as contrast agents for MRI applications like diagnosis and follow-up of infectious diseases, among others. Importantly, with the first generation radical dendrimer, a similar r1 relaxivity value (3.4 mM−1s−1) in comparison to gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) used in clinics (3.2 mM−1s−1, r.t. 7T) has been obtained, and it has been shown to not be cytotoxic, avoiding the toxicity risks associated with the unwanted accumulation of Gd in the body. | - |
dc.description.sponsorship | This research was funded by the Spanish Government (PID2019-105622RB-I00, MAT2016-80826-R, CTQ2017-90596-REDT and Severo Ochoa FUNMAT-FIP-2018 (J.V.) and SAF-2014-60138-R and RTI2018-093831-B-I00 (M.R.), CSIC (intramural 201760E080 project), CIBER BBN (CB06/01/0033, CB06/01/0074 and intramural ORDECA project) and Generalitat de Catalunya (2017-SGR-918 and 2017-SGR-1439). ICMAB acknowledges Spanish MINECO through the Severo Ochoa Centres of Excellence Programme Grant SEV- 2015-0496. | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105622RB-I00 | - |
dc.relation | PID2019-105622RB-I00/AEI/10.13039/501100011033 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2016-80826-R | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-90596-REDT | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FUNMAT-FIP-2018 | - |
dc.relation | CTQ2017-90596-REDT/AEI/10.13039/501100011033 | - |
dc.relation | FUNMAT-FIP-2018/AEI/10.13039/501100011033 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF-2014-60138-R | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093831-B-I00 | - |
dc.relation | RTI2018-093831-B-I00/AEI/10.13039/501100011033 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV- 2015-0496 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Contrast agent | - |
dc.subject | Magnetic resonance imaging (MRI) | - |
dc.subject | Organic radicals | - |
dc.subject | PROXYL | - |
dc.subject | OEG dendrimers | - |
dc.subject | Radical dendrimers | - |
dc.subject | Relaxivity | - |
dc.subject | Gd-DTPA | - |
dc.subject | Infectious diseases | - |
dc.title | Radical dendrimers based on biocompatible oligoethylene glycol dendrimers as contrast agents for MRI | - |
dc.identifier.doi | 10.3390/pharmaceutics12080772 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | https://doi.org/10.3390/pharmaceutics12080772 | - |
dc.identifier.e-issn | 1999-4923 | - |
dc.date.updated | 2020-08-21T14:00:19Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | Generalitat de Catalunya | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
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