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Title

Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushrooms

AuthorsAnnang, Frederick; Pérez-Victoria, Ignacio; Appiah, Theresa; Pérez-Moreno, Guiomar; Domingo, Elizabeth; Martín, Jesús; Mackenzie, Thomas; Ruiz-Pérez, Luis Miguel; González-Pacanowska, D.; Genilloud, Olga; Vicente, Francisca; Agyare, Christian; Reyes, Fernando
KeywordsBioassay-guided isolation
Mushrooms
Natural products
Protozoan parasites
Terpenes
Tropical diseases
Issue Date2018
PublisherElsevier BV
CitationFitoterapia
AbstractBioassay-guided compound isolation led to the discovery of two new scalarane sesterterpenes (1 and 2) and two new triterpenes (3 and 4) from two mushroom species, Pleurotus ostreatus (edible) and Scleroderma areolatum, collected from Ghana. Their structures, including absolute stereochemistry, were established by spectroscopic methods, particularly (+)-ESI-TOF mass spectrometry and 1D and 2D NMR. The four compounds exhibited IC50 values of 1.65-7.63 μM against Plasmodium falciparum 3D7 and 5.04-13.65 μM against Trypanosoma cruzi Tulahuen C4 parasites and were also non-cytotoxic against HepG2 tumoral human liver cells. This is the first report describing the isolation of sesterterpenes belonging to the scalarane structural class from a terrestrial source.
Publisher version (URL)http://dx.doi.org/10.1016/j.fitote.2018.03.016
URIhttp://hdl.handle.net/10261/200010
DOI10.1016/j.fitote.2018.03.016
Identifiersdoi: 10.1016/j.fitote.2018.03.016
issn: 0367-326X
e-issn: 1873-6971
Appears in Collections:(IPBLN) Artículos




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