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http://hdl.handle.net/10261/200010
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dc.contributor.author | Annang, Frederick | - |
dc.contributor.author | Pérez-Victoria, Ignacio | - |
dc.contributor.author | Appiah, Theresa | - |
dc.contributor.author | Pérez-Moreno, Guiomar | - |
dc.contributor.author | Domingo, Elizabeth | - |
dc.contributor.author | Martín, Jesús | - |
dc.contributor.author | Mackenzie, Thomas | - |
dc.contributor.author | Ruiz-Pérez, Luis Miguel | - |
dc.contributor.author | González-Pacanowska, Dolores | - |
dc.contributor.author | Genilloud, Olga | - |
dc.contributor.author | Vicente, Francisca | - |
dc.contributor.author | Agyare, Christian | - |
dc.contributor.author | Reyes, Fernando | - |
dc.date.accessioned | 2020-02-07T12:18:03Z | - |
dc.date.available | 2020-02-07T12:18:03Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.1016/j.fitote.2018.03.016 | - |
dc.identifier | issn: 0367-326X | - |
dc.identifier | e-issn: 1873-6971 | - |
dc.identifier.citation | Fitoterapia | - |
dc.identifier.uri | http://hdl.handle.net/10261/200010 | - |
dc.description.abstract | Bioassay-guided compound isolation led to the discovery of two new scalarane sesterterpenes (1 and 2) and two new triterpenes (3 and 4) from two mushroom species, Pleurotus ostreatus (edible) and Scleroderma areolatum, collected from Ghana. Their structures, including absolute stereochemistry, were established by spectroscopic methods, particularly (+)-ESI-TOF mass spectrometry and 1D and 2D NMR. The four compounds exhibited IC50 values of 1.65-7.63 μM against Plasmodium falciparum 3D7 and 5.04-13.65 μM against Trypanosoma cruzi Tulahuen C4 parasites and were also non-cytotoxic against HepG2 tumoral human liver cells. This is the first report describing the isolation of sesterterpenes belonging to the scalarane structural class from a terrestrial source. | - |
dc.description.sponsorship | The present work was funded by the European Commission FP7 Marie Curie Initial Training Network >ParaMet> (grant agreement 290080), ISCIII Project >RD16/0027/0015> Tropical Diseases Network, Subprogram RETICS from Plan Estatal de I + D + I 2013-2016 and co-financed by FEDER: A way to make Europe. The polarimeter, HPLC, IR, NMR equipment, and plate reader used in this work were purchased via grants for scientific and technological infrastructures from the Ministerio de Ciencia e Innovacion [Grants No. PCT-010000-2010-4 (NMR), INP-2011-0016-PCT-010000 ACT6 (polarimeter, HPLC, and IR), and PCT-01000-ACTT, 2011-13 (plate reader)]. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RD16/0027/0015 | - |
dc.relation | Ministerio de Ciencia e Innovacion/PCT-010000-2010-4 (NMR), INP-2011-0016-PCT-010000 ACT6 | - |
dc.relation | PCT-01000-ACTT, 2011-13 | - |
dc.rights | closedAccess | - |
dc.subject | Bioassay-guided isolation | - |
dc.subject | Mushrooms | - |
dc.subject | Natural products | - |
dc.subject | Protozoan parasites | - |
dc.subject | Terpenes | - |
dc.subject | Tropical diseases | - |
dc.title | Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushrooms | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.fitote.2018.03.016 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.fitote.2018.03.016 | - |
dc.date.updated | 2020-02-07T12:18:04Z | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
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