Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/196002
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Pheomelanin molecular vibration is associated with mitochondrial ROS production in melanocytes and systemic oxidative stress and damage |
Autor: | Galván, Ismael CSIC ORCID ; Jorge García, Alberto CSIC ORCID; Garcia-Gil, María | Fecha de publicación: | 2017 | Editor: | Oxford University Press | Citación: | Integrative Biology 9(9): 751-761 (2017) | Resumen: | Vibrations in covalent bonds affect electron delocalization within molecules, as reported in polymers. If synthesized by living cells, the electron delocalization of polymers affects the stabilization of cellular free radicals, but biomolecular vibration has never been considered a potential source of cytotoxicity. Here we show that the vibrational characteristics of natural pheomelanin and eumelanin contribute to feather color expression in four poultry breeds with different melanin-based pigmentation patterns, but only the vibrational characteristics of pheomelanin are related to the production of reactive oxygen species (ROS) in the mitochondria of melanocytes and to systemic levels of cellular oxidative stress and damage. This association may be explained by the close physical contact existing between mitochondria and melanosomes, and reveals an unprecedented factor affecting the viability of organisms through their pigmentation. These findings open a new avenue for understanding the mechanism linking pheomelanin synthesis to human melanoma risk. | Versión del editor: | https://doi.org/10.1039/c7ib00107j | URI: | http://hdl.handle.net/10261/196002 | DOI: | 10.1039/c7ib00107j | ISSN: | 1757-9694 | E-ISSN: | 1757-9708 |
Aparece en las colecciones: | (MNCN) Artículos (EBD) Artículos (INIA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
8
checked on 16-may-2024
WEB OF SCIENCETM
Citations
9
checked on 23-feb-2024
Page view(s)
179
checked on 22-may-2024
Download(s)
22
checked on 22-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.