Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/196002
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorGalván, Ismael-
dc.contributor.authorJorge García, Alberto-
dc.contributor.authorGarcia-Gil, María-
dc.date.accessioned2019-12-04T10:18:25Z-
dc.date.available2019-12-04T10:18:25Z-
dc.date.issued2017-
dc.identifier.citationIntegrative Biology 9(9): 751-761 (2017)-
dc.identifier.issn1757-9694-
dc.identifier.urihttp://hdl.handle.net/10261/196002-
dc.description.abstractVibrations in covalent bonds affect electron delocalization within molecules, as reported in polymers. If synthesized by living cells, the electron delocalization of polymers affects the stabilization of cellular free radicals, but biomolecular vibration has never been considered a potential source of cytotoxicity. Here we show that the vibrational characteristics of natural pheomelanin and eumelanin contribute to feather color expression in four poultry breeds with different melanin-based pigmentation patterns, but only the vibrational characteristics of pheomelanin are related to the production of reactive oxygen species (ROS) in the mitochondria of melanocytes and to systemic levels of cellular oxidative stress and damage. This association may be explained by the close physical contact existing between mitochondria and melanosomes, and reveals an unprecedented factor affecting the viability of organisms through their pigmentation. These findings open a new avenue for understanding the mechanism linking pheomelanin synthesis to human melanoma risk.-
dc.description.sponsorshipIG is supported by a Ramón y Cajal Fellowship (RYC-2012-10237) from the Spanish Ministry of Economy and Competitiveness, and funded by the project IN[15]CMA_CMA_1422 from Fundación BBVA (‘Convocatoria 2015 de ayudas Fundación BBVA a investigadores y creadores culturales’).-
dc.publisherOxford University Press-
dc.rightsclosedAccess-
dc.titlePheomelanin molecular vibration is associated with mitochondrial ROS production in melanocytes and systemic oxidative stress and damage-
dc.typeartículo-
dc.identifier.doi10.1039/c7ib00107j-
dc.relation.publisherversionhttps://doi.org/10.1039/c7ib00107j-
dc.identifier.e-issn1757-9708-
dc.date.updated2019-12-04T10:18:25Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderFundación BBVA-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/100007406es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Aparece en las colecciones: (MNCN) Artículos
(EBD) Artículos
(INIA) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Show simple item record

CORE Recommender

SCOPUSTM   
Citations

8
checked on 06-may-2024

WEB OF SCIENCETM
Citations

9
checked on 23-feb-2024

Page view(s)

178
checked on 11-may-2024

Download(s)

22
checked on 11-may-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.