Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/188859
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Modelling physical resilience in ageing mice |
Autor: | Schosserer, Markus; Banks, Gareth; Dogan, Soner; Dungel, Peter; Fernandes, Adelaide; Marolt Presen, Darja; Matheu, Ander; Osuchowski, Marcin; Potter, Paul; Sanfeliu, Coral CSIC ORCID; Guvenc Tuna, Bilge; Varela-Nieto, Isabel CSIC ORCID ; Bellantuono, Ilaria | Palabras clave: | Ageing Physical resilience Mouse models Frailty Stress recovery Intervention testing |
Fecha de publicación: | 2019 | Editor: | Elsevier | Citación: | Mechanisms of Ageing and Development 177: 91-102 (2019) | Resumen: | Geroprotectors, a class of drugs targeting multiple deficits occurring with age, necessitate the development of new animal models to test their efficacy. The COST Action MouseAGE is a European network whose aim is to reach consensus on the translational path required for geroprotectors, interventions targeting the biology of ageing. In our previous work we identified frailty and loss of resilience as a potential target for geroprotectors. Frailty is the result of an accumulation of deficits, which occurs with age and reduces the ability to respond to adverse events (physical resilience). Modelling frailty and physical resilience in mice is challenging for many reasons. There is no consensus on the precise definition of frailty and resilience in patients or on how best to measure it. This makes it difficult to evaluate available mouse models. In addition, the characterization of those models is poor. Here we review potential models of physical resilience, focusing on those where there is some evidence that the administration of acute stressors requires integrative responses involving multiple tissues and where aged mice showed a delayed recovery or a worse outcome then young mice in response to the stressor. These models include sepsis, trauma, drug- and radiation exposure, kidney and brain ischemia, exposure to noise, heat and cold shock. | Versión del editor: | https://doi.org/10.1016/j.mad.2018.10.001 | URI: | http://hdl.handle.net/10261/188859 | DOI: | 10.1016/j.mad.2018.10.001 | ISSN: | 0047-6374 | E-ISSN: | 1872-6216 |
Aparece en las colecciones: | (IIBM) Artículos (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
modellmice.pdf | 475,94 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
3
checked on 22-abr-2024
SCOPUSTM
Citations
15
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
12
checked on 25-feb-2024
Page view(s)
170
checked on 26-abr-2024
Download(s)
103
checked on 26-abr-2024