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Título: | A Dynamic Chemical Network for Cystinuria Diagnosis |
Autor: | Lafuente, Maria CSIC; Solà Oller, Jordi CSIC ORCID ; Alfonso, Ignacio CSIC ORCID | Palabras clave: | Dynamics Chemistry Dynamic combinatorial |
Fecha de publicación: | 9-jul-2018 | Editor: | Wiley-VCH | Citación: | Angewandte Chemie - International Edition 57 (28): 8421-8424 (2018) | Resumen: | The study of molecular networks represents a conceptual revolution in chemistry. Building on previous knowledge and after understanding the rules of non-covalent interactions, the design of stimulus-responsive chemical systems is possible. Herein we report a new strategy, based on the reorganization of a dynamic chemical network that generates new fluorescent associations in the presence of cysteine or cystine. The binding and sensing units are encoded in the components that dynamically assemble and disassemble responding to external stimuli as a successful tool to detect both cysteine and cystine in aqueous media. Moreover, the dynamic sensing system works in human urine, as a prospective application for cystinuria diagnosis. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim | Versión del editor: | https://doi.org/10.1002/anie.201802189 | URI: | http://hdl.handle.net/10261/179241 | DOI: | 10.1002/anie.201802189 |
Aparece en las colecciones: | (IQAC) Artículos |
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A dynamic chemical network.pdf | 1,02 MB | Adobe PDF | Visualizar/Abrir |
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