Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/171465
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Muñoz Santiago, Silvia | - |
dc.contributor.author | Méndez, Lucía | - |
dc.contributor.author | Dasilva, Gabriel | - |
dc.contributor.author | Torres, Josep Lluís | - |
dc.contributor.author | Ramos-Romero, Sara | - |
dc.contributor.author | Romeu, Marta | - |
dc.contributor.author | Nogués, M. R. | - |
dc.contributor.author | Medina, Isabel | - |
dc.date.accessioned | 2018-10-24T08:16:39Z | - |
dc.date.available | 2018-10-24T08:16:39Z | - |
dc.date.issued | 2018-09-26 | - |
dc.identifier.citation | Marine Drugs 16(10): 353 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/171465 | - |
dc.description.abstract | The present study addressed the ability of long-chain ω-3 polyunsaturated fatty acids (ω-3 PUFA), i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), to ameliorate liver protein damage derived from oxidative stress and induced by consumption of high-caloric diets, typical of Westernized countries. The experimental design included an animal model of Sprague-Dawley rats fed high-fat high-sucrose (HFHS) diet supplemented with ω-3 EPA and DHA for a complete hepatic proteome analysis to map carbonylated proteins involved in specific metabolic pathways. Results showed that the intake of marine ω-3 PUFA through diet significantly decreased liver protein carbonylation caused by long-term HFHS consumption and increased antioxidant system. Fish oil modulated the carbonylation level of more than twenty liver proteins involved in critical metabolic pathways, including lipid metabolism (e.g., albumin), carbohydrate metabolism (e.g., pyruvate carboxylase), detoxification process (e.g., aldehyde dehydrogenase 2), urea cycle (e.g., carbamoyl-phosphate synthase), cytoskeleton dynamics (e.g., actin), or response to oxidative stress (e.g., catalase) among others, which might be under the control of diet marine ω-3 PUFA. In parallel, fish oil significantly changed the liver fatty acid profile given by the HFHS diet, resulting in a more anti-inflammatory phenotype. In conclusion, the present study highlights the significance of marine ω-3 PUFA intake for the health of rats fed a Westernized diet by describing several key metabolic pathways which are protected in liver. | - |
dc.description.sponsorship | This research was founded by the Spanish Ministry of Science and Innovation (grant number AGL2013-49079-C2-1-R) and The Consejo Superior de Investigaciones Científicas (CSIC). Both are gratefully acknowledged for the doctoral fellowship to Silvia Muñoz Xunta de Galicia is also thankfully recognized for the financial support of the postdoctoral contract to Lucía Méndez The authors thank Lorena Barros, Salomé Lois and Maria Jesus González for their technical assistance. | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-49079-C2-1-R | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Oxidative stress | - |
dc.subject | High-fat high-sucrose diet | - |
dc.subject | Liver protein damage | - |
dc.subject | Marine omega-3 fatty acids | - |
dc.subject | Carbonylation | - |
dc.subject | Fish oils | - |
dc.subject | Sprague-dawley rat | - |
dc.title | Targeting hepatic protein carbonylation and oxidative stress occurring on diet-induced metabolic diseases through the supplementation with fish oils. | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/md16100353 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | https://doi.org/10.3390/md16100353 | - |
dc.identifier.e-issn | 1660-3397 | - |
dc.date.updated | 2018-10-24T08:16:40Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | Xunta de Galicia | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010801 | es_ES |
dc.identifier.pmid | 30261666 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Aparece en las colecciones: | (IIM) Artículos (IQAC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
marinedrugs-16-00353.pdf | 3,22 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
11
checked on 10-may-2024
SCOPUSTM
Citations
20
checked on 22-may-2024
WEB OF SCIENCETM
Citations
20
checked on 28-feb-2024
Page view(s)
267
checked on 22-may-2024
Download(s)
456
checked on 22-may-2024