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http://hdl.handle.net/10261/168468
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dc.contributor.author | García-Ramírez, Idoia | - |
dc.contributor.author | Martín-Lorenzo, Alberto | - |
dc.contributor.author | González-Herrero, Inés | - |
dc.contributor.author | Rodríguez-Hernández, Guillermo | - |
dc.contributor.author | Vicente-Dueñas, Carolina | - |
dc.contributor.author | Sánchez García, Isidro | - |
dc.date.accessioned | 2018-08-09T07:23:28Z | - |
dc.date.available | 2018-08-09T07:23:28Z | - |
dc.date.issued | 2016 | - |
dc.identifier | doi: 10.3390/ijms17060889 | - |
dc.identifier | e-issn: 1422-0067 | - |
dc.identifier | issn: 1661-6596 | - |
dc.identifier.citation | International Journal of Molecular Sciences 17(6): 889 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/168468 | - |
dc.description.abstract | Leukemic stem cells (LSCs) are defined as cells that possess the ability to self-renew and give rise to the differentiated cancer cells that comprise the tumor. These LSCs seem to show chemo-resistance and radio-resistance leading to the failure of conventional cancer therapies. Current therapies are directed at the fast growing tumor mass leaving the LSC fraction untouched. Eliminating LSCs, the root of cancer origin and recurrence, is considered to be a hopeful approach to improve survival or even to cure cancer patients. In order to achieve this, the characterization of LSCs is a prerequisite in order to develop LSC-based therapies to eliminate them. Here we review if vitamin D analogues may allow an avenue to target the LSCs. | - |
dc.description.sponsorship | Research in Isidro Sánchez-García group is partially supported by FEDER and by MINECO (SAF2012-32810, SAF2015-64420-R, and Red de Excelencia Consolider OncoBIO SAF2014-57791-REDC), Instituto de Salud Carlos III (PIE14/00066), ISCIII-Plan de Ayudas IBSAL 2015 Proyectos Integrados (IBY15/00003), by Junta de Castilla y León (BIO/SA51/15, CSI001U14, and UIC-017), by the German Carreras Foundation (DJCLS R13/26), Fundacion Inocente Inocente, and by the ARIMMORA project (European Union’s Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 282891). Isidro Sánchez-García lab is a member of the EuroSyStem and the DECIDE Network funded by the European Union under the FP7 program. Research in Carolina Vicente-Dueñas group is partially supported by a “Miguel Servet” Grant (CP14/00082-AES 2013–2016 FEDER) from the Instituto de Salud Carlos III (Ministerio de Economía y Competitividad). Guillermo Rodriguez-Hernández and Alberto Martín-Lorenzo were supported by FSE-Conserjería de Educación de la Junta de Castilla y León. | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/282891 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-57791-REDC | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-64420-R | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Stem cells | - |
dc.subject | Vitamin D | - |
dc.subject | Cancer | - |
dc.subject | Cancer stem cells | - |
dc.subject | Mouse models | - |
dc.subject | Leukemia therapy | - |
dc.title | Could vitamin D analogues be used to target leukemia stem cells? | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/ijms17060889 | - |
dc.relation.publisherversion | https://doi.org/10.3390/ijms17060889 | - |
dc.date.updated | 2018-08-09T07:23:28Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Junta de Castilla y León | - |
dc.contributor.funder | Fundación Inocente Inocente | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100014180 | es_ES |
dc.identifier.pmid | 27275819 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IBMCC) Artículos |
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Dvitamincell.pdf | 1,3 MB | Adobe PDF | Visualizar/Abrir |
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