2024-03-28T22:51:40Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1684682020-12-13T09:17:45Zcom_10261_112com_10261_1col_10261_365
2018-08-09T07:23:28Z
urn:hdl:10261/168468
Could vitamin D analogues be used to target leukemia stem cells?
García-Ramírez, Idoia
Martín-Lorenzo, Alberto
González-Herrero, Inés
Rodríguez-Hernández, Guillermo
Vicente-Dueñas, Carolina
Sánchez García, Isidro
European Commission
Ministerio de Economía y Competitividad (España)
Instituto de Salud Carlos III
Junta de Castilla y León
Fundación Inocente Inocente
Stem cells
Vitamin D
Cancer
Cancer stem cells
Mouse models
Leukemia therapy
Leukemic stem cells (LSCs) are defined as cells that possess the ability to self-renew and give rise to the differentiated cancer cells that comprise the tumor. These LSCs seem to show chemo-resistance and radio-resistance leading to the failure of conventional cancer therapies. Current therapies are directed at the fast growing tumor mass leaving the LSC fraction untouched. Eliminating LSCs, the root of cancer origin and recurrence, is considered to be a hopeful approach to improve survival or even to cure cancer patients. In order to achieve this, the characterization of LSCs is a prerequisite in order to develop LSC-based therapies to eliminate them. Here we review if vitamin D analogues may allow an avenue to target the LSCs.
2018-08-09T07:23:28Z
2018-08-09T07:23:28Z
2016
2018-08-09T07:23:28Z
artículo
International Journal of Molecular Sciences 17(6): 889 (2016)
http://hdl.handle.net/10261/168468
10.3390/ijms17060889
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100014180
27275819
eng
Publisher's version
https://doi.org/10.3390/ijms17060889
Sí
info:eu-repo/grantAgreement/EC/FP7/282891
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-57791-REDC
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-64420-R
http://creativecommons.org/licenses/by/4.0/
openAccess
Multidisciplinary Digital Publishing Institute