Prognosis value of exosomal ΔNp73 in colon cancer patients

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Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Bonilla, Félix	es_ES
dc.contributor.author	Domínguez, Gemma	es_ES
dc.date.accessioned	2017-07-13T10:45:52Z	-
dc.date.available	2017-07-13T10:45:52Z	-
dc.date.issued	2015	-
dc.identifier.citation	2nd Symposium on Biomedical Research (2015)	es_ES
dc.identifier.uri	http://hdl.handle.net/10261/152720	-
dc.description	Resumen del póster presentado al 2nd Symposium on Biomedical Research: "Advances and perspectives in cancer", celebrado en Madrid el 17 de abril de 2015.-- et al.	es_ES
dc.description.abstract	[Objetive]: Tumor-derived exosomes are emerging as local and systemic cell-to-cell mediators of oncogenic information through the horizontal transfer of mRNAs, microRNAs and proteins. The exosomal content has been described as active when taken up by the recipient cell. Identifying the specific molecular cargo of exosomes will help to determine their function. [Design]: We have evaluated by RT-PCR the levels of ΔNp73 in colon cancer patients derived exosomes and analyzed its prognosis potential. [Results]: We have observed that ΔNp73 messenger is enriched in tumor-derived exosomes. High levels of ΔNp73 in exosomes of colon cancer patients associated with shorter survivals. [Conclusion]: ΔNp73 can be actively sorted in tumor-derived exosomes. Our data support the potential prognostic value of exosomal ΔNp73 in colon cancer patients, with the advantage of obtaining the sample through a non-invasive method.	es_ES
dc.language.iso	eng	es_ES
dc.publisher	CSIC-UAM - Instituto de Investigaciones Biomédicas Alberto Sols (IIBM)	es_ES
dc.rights	closedAccess	es_ES
dc.title	Prognosis value of exosomal ΔNp73 in colon cancer patients	es_ES
dc.type	póster de congreso	es_ES
dc.description.peerreviewed	Peer reviewed	es_ES
dc.relation.csic	Sí	es_ES
oprm.item.hasRevision	no ko 0 false	*
dc.type.coar	http://purl.org/coar/resource_type/c_6670	es_ES
item.cerifentitytype	Publications	-
item.openairecristype	http://purl.org/coar/resource_type/c_18cf	-
item.grantfulltext	none	-
item.openairetype	póster de congreso	-
item.fulltext	No Fulltext	-
item.languageiso639-1	en	-
Aparece en las colecciones:	(IIBM) Comunicaciones congresos