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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/147718
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dc.contributor.authorCornudella, R.-
dc.contributor.authorMoreno, José Antonio-
dc.contributor.authorPiñol, Rafael-
dc.contributor.authorPalacio, Fernando-
dc.contributor.authorMorales, M. P.-
dc.contributor.authorMillán, Ángel-
dc.date.accessioned2017-03-31T11:29:06Z-
dc.date.available2017-03-31T11:29:06Z-
dc.date.issued2015-
dc.identifierdoi: 10.1039/c4Tx00241e-
dc.identifierissn: 2045-4538-
dc.identifiere-issn: 2045-452X-
dc.identifier.citationToxicology Research 4(6): 1555-1564 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/147718-
dc.descriptionAccepted Manuscript.-- et al.-
dc.description.abstractHematotoxicity of magnetite nanoparticles coated with dimercaptosuccinic acid (DMSA) and polyethylene glycol (PEG) has been evaluated by determining their safety in vitro and in vivo in a rat model up to 30 days after administration of a single dose. The in vitro analysis consists of global plasma coagulation (PT, aPTT, and fibrinogen) and platelet aggregation tests while the hematotoxicity studies in vivo include a complete blood count and the possible genotoxic effect analysis in the bone marrow hematopoietic function. Prolonged aPTT values indicate a higher anticoagulant effect for NP-DMSA compared with PEG-coated nanoparticles as a consequence of the higher surface charge of the former. The in vivo tests showed that these bioferrofluids do not cause genotoxic effects, affect erythropoiesis or increase the number of immature erythrocytes in the bone marrow at the analyzed dose. However, nanoparticle administration showed a significant effect on the leukocyte counts in animals treated with DMSA coated nanoparticles 24 h after injection. This response is not observed in animals treated with PEG modified nanoparticles which justifies the use of this polymer in biomasking strategies.-
dc.description.sponsorshipL.M.A.A. acknowledges financial support from the Spanish Ministry of Science and Innovation FPI research grants. Technical support from the University Hospital Lozano Blesa, Zaragoza, Spain and from María Angeles Gracia, Ana Isabel Martínez de Ternero, Maria Rosa Borrell Sanz. AR holds a predoctoral fellowship from a CSIC-CITMA collaborative project (B01CU2009; ICMM, 2011–2014) and a short-term fellowship from CNPq (DTI-2; 383934/2013-3). This work was partially supported by grants from the Spanish Ministry of Economy and Competitiveness (MAT2011-23641 and MAT2011-25991).-
dc.publisherRoyal Society of Chemistry (UK)-
dc.relation.isversionofPostprint-
dc.rightsopenAccess-
dc.titleHematotoxicity of magnetite nanoparticles coated with polyethylene glycol: in vitro and in vivo studies-
dc.typeartículo-
dc.identifier.doi10.1039/c4Tx00241e-
dc.relation.publisherversionhttps://doi.org/10.1039/c4Tx00241e-
dc.date.updated2017-03-31T11:29:06Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderConselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.relation.csicSí-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003593es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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