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Tissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System during Development and Disease

AuthorsSebastián-Serrano, Álvaro; Diego-García, Laura de; Martínez-Frailes, Carlos; Ávila, Jesús ; Zimmermann, Herbert; Millán, José Luis; Miras Portugal, María Teresa; Díaz-Hernández, Miguel
KeywordsPyridoxal phosphate
Neurodegenerative diseases
Issue Date15-Dec-2014
CitationComputational and Structural Biotechnology Journal 13: 95- 100 (2015)
AbstractTissue-nonspecific alkaline phosphatase (TNAP) is one of the four isozymes in humans and mice that have the capacity to hydrolyze phosphate groups from a wide spectrum of physiological substrates. Among these, TNAP degrades substrates implicated in neurotransmission. Transgenic mice lacking TNAP activity display the characteristic skeletal and dental phenotype of infantile hypophosphatasia, as well as spontaneous epileptic seizures and die around 10 days after birth. This physiopathology, linked to the expression pattern of TNAP in the central nervous system (CNS) during embryonic stages, suggests an important role for TNAP in neuronal development and synaptic function, situating it as a good target to be explored for the treatment of neurological diseases. In this review, we will focus mainly on the role that TNAP plays as an ectonucleotidase in CNS regulating the levels of extracellular ATP and consequently purinergic signaling.
Identifiersdoi: 10.1016/j.csbj.2014.12.004
issn: 2001-0370
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