English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/142665
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Tissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System during Development and Disease

AutorSebastián-Serrano, Álvaro; Diego-García, Laura de; Martínez-Frailes, Carlos; Ávila, Jesús ; Zimmermann, Herbert; Millán, José Luis; Miras Portugal, María Teresa; Díaz-Hernández, Miguel
Palabras clavePyridoxal phosphate
Neurodegenerative diseases
Fecha de publicación15-dic-2014
CitaciónComputational and Structural Biotechnology Journal 13: 95- 100 (2015)
ResumenTissue-nonspecific alkaline phosphatase (TNAP) is one of the four isozymes in humans and mice that have the capacity to hydrolyze phosphate groups from a wide spectrum of physiological substrates. Among these, TNAP degrades substrates implicated in neurotransmission. Transgenic mice lacking TNAP activity display the characteristic skeletal and dental phenotype of infantile hypophosphatasia, as well as spontaneous epileptic seizures and die around 10 days after birth. This physiopathology, linked to the expression pattern of TNAP in the central nervous system (CNS) during embryonic stages, suggests an important role for TNAP in neuronal development and synaptic function, situating it as a good target to be explored for the treatment of neurological diseases. In this review, we will focus mainly on the role that TNAP plays as an ectonucleotidase in CNS regulating the levels of extracellular ATP and consequently purinergic signaling.
Identificadoresdoi: 10.1016/j.csbj.2014.12.004
issn: 2001-0370
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
ÁvilaJ_Tissue-nonspecificAlkalinePhosphatase.pdf915,28 kBAdobe PDFVista previa
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.