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dc.contributor.authorSebastián-Serrano, Álvaro-
dc.contributor.authorDiego-García, Laura de-
dc.contributor.authorMartínez-Frailes, Carlos-
dc.contributor.authorÁvila, Jesús-
dc.contributor.authorZimmermann, Herbert-
dc.contributor.authorMillán, José Luis-
dc.contributor.authorMiras Portugal, María Teresa-
dc.contributor.authorDíaz-Hernández, Miguel-
dc.date.accessioned2017-01-18T09:51:25Z-
dc.date.available2017-01-18T09:51:25Z-
dc.date.issued2014-12-15-
dc.identifierdoi: 10.1016/j.csbj.2014.12.004-
dc.identifierissn: 2001-0370-
dc.identifier.citationComputational and Structural Biotechnology Journal 13: 95- 100 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/142665-
dc.description.abstractTissue-nonspecific alkaline phosphatase (TNAP) is one of the four isozymes in humans and mice that have the capacity to hydrolyze phosphate groups from a wide spectrum of physiological substrates. Among these, TNAP degrades substrates implicated in neurotransmission. Transgenic mice lacking TNAP activity display the characteristic skeletal and dental phenotype of infantile hypophosphatasia, as well as spontaneous epileptic seizures and die around 10 days after birth. This physiopathology, linked to the expression pattern of TNAP in the central nervous system (CNS) during embryonic stages, suggests an important role for TNAP in neuronal development and synaptic function, situating it as a good target to be explored for the treatment of neurological diseases. In this review, we will focus mainly on the role that TNAP plays as an ectonucleotidase in CNS regulating the levels of extracellular ATP and consequently purinergic signaling.-
dc.description.sponsorshipMinisterio de Ciencia e Innovación-
dc.publisherElsevier-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.subjectPyridoxal phosphate-
dc.subjectATP-
dc.subjectTNAP-
dc.subjectNeurodegenerative diseases-
dc.subjectDevelopment-
dc.subjectP2X7R-
dc.titleTissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System during Development and Disease-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1016/j.csbj.2014.12.004-
dc.date.updated2017-01-18T09:51:27Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
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