Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/124998
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Image guided drug release from pH-sensitive Ion channel-functionalized stealth liposomes into an in vivo glioblastoma model |
Autor: | Pacheco-Torres, Jesús CSIC ORCID ; Mukherjee, Nobina; Walko, Martin; López-Larrubia, Pilar CSIC ORCID; Ballesteros, Paloma CSIC ORCID; Cerdán, Sebastián CSIC ORCID; Kocer, Armagan | Palabras clave: | C6 glioma tumors Triggered drug delivery Ion channel engineering Mechanosensitive channel of large conductance pH-sensitive liposomes Magnetic resonance spectroscopy and imaging |
Fecha de publicación: | 2015 | Editor: | Elsevier | Citación: | Nanomedicine: Nanotechnology, Biology, and Medicine 11(6): 1345-1354 (2015) | Resumen: | Liposomal drug delivery vehicles are promising nanomedicine tools for bringing cytotoxic drugs to cancerous tissues selectively. However, the triggered cargo release from liposomes in response to a target-specific stimulus has remained elusive. We report on functionalizing stealth-liposomes with an engineered ion channel and using these liposomes in vivo for releasing an imaging agent into a cerebral glioma rodent model. If the ambient pH drops below a threshold value, the channel generates temporary pores on the liposomes, thus allowing leakage of the intraluminal medicines. By using magnetic resonance spectroscopy and imaging, we show that engineered liposomes can detect the mildly acidic pH of the tumor microenvironment with 0.2 pH unit precision and they release their content into C6 glioma tumors selectively, in vivo. A drug delivery system with this level of sensitivity and selectivity to environmental stimuli may well serve as an optimal tool for environmentally-triggered and image-guided drug release. From the Clinical Editor: Cancer remains a leading cause of mortality worldwide. With advances in science, delivery systems of anti-cancer drugs have also become sophisticated. In this article, the authors designed and characterized functionalized liposomal vehicles, which would release the drug payload in a highly sensitive manner in response to a change in pH environment in an animal glioma model. The novel data would enable better future designs of drug delivery systems |
URI: | http://hdl.handle.net/10261/124998 | DOI: | 10.1016/j.nano.2015.03.014 | Identificadores: | doi: 10.1016/j.nano.2015.03.014 issn: 1549-9634 |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
40
checked on 07-may-2024
WEB OF SCIENCETM
Citations
35
checked on 23-feb-2024
Page view(s)
251
checked on 16-may-2024
Download(s)
117
checked on 16-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.