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http://hdl.handle.net/10261/123117
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Díaz-Toledano, Rosa | es_ES |
dc.contributor.author | Ariza-Mateos, Ascensión | es_ES |
dc.contributor.author | Birk, A. | es_ES |
dc.contributor.author | Martínez-García, Belén | es_ES |
dc.contributor.author | Gómez-Castilla, Jordi | es_ES |
dc.date.accessioned | 2015-10-07T11:26:59Z | - |
dc.date.available | 2015-10-07T11:26:59Z | - |
dc.date.issued | 2009-07 | - |
dc.identifier.citation | Nucleic Acids Research | es_ES |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | http://hdl.handle.net/10261/123117 | - |
dc.description | Supplementari Data http://nar.oxfordjournals.org/content/suppl/2009/10/12/gkp553.DC1 | es_ES |
dc.description.abstract | It has been proposed that the hepatitis C virus (HCV) internal ribosome entry site (IRES) resides within a locked conformation, owing to annealing of its immediate flanking sequences. In this study, structure probing using Escherichia coli dsRNA-specific RNase III and other classical tools showed that this region switches to an open conformation triggered by the liver-specific microRNA, miR-122. This structural transition, observed in vitro, may be the mechanistic basis for the involvement of downstream IRES structural domain VI in translation, as well as providing a role of liver-specific miR-122 in HCV infection. In addition, the induced RNA switching at the 5′ untranslated region could ultimately represent a new mechanism of action of micro-RNAs. | es_ES |
dc.description.sponsorship | Ministerio de Ciencia e Innovación BIO2007-60106, BIO2004-06114 Proyecto Excelencia Comunidad Autónoma de Andalucía CVI-03050; FISS (CIBERehd); FIPSE 36549/06 for work in Granada; National Institutes of Health grant NIH/NIDA K01 DAO18262 for work in Doylestown, Pennsylvania. Funding for open access charge: BIO-2007, 60106 (IPB-LN) CSIC. MCyT. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.title | In vitro characterization of a miR-122-sensitive double-helical switch element in the 5′ region of hepatitis C virus RNA | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1093/nar/gkp553 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://nar.oxfordjournals.org/content/early/2009/07/03/nar.gkp553.full | es_ES |
dc.identifier.e-issn | 1362-4962 | - |
dc.rights.license | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Junta de Andalucía | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España) | es_ES |
dc.contributor.funder | Fundación para la Investigación y la Prevención del Sida en España | es_ES |
dc.contributor.funder | National Institutes of Health (US) | es_ES |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007671 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100000002 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 19578061 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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In_vitro-characterization.pdf | 17,64 MB | Adobe PDF | Visualizar/Abrir |
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