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dc.contributor.authorIbáñez Pereda, Jaime-
dc.contributor.authorGonzález de la Aleja, Jesús-
dc.contributor.authorGallego, Juan Álvaro-
dc.contributor.authorRomero, Juan Pablo-
dc.contributor.authorSaíz-Díaz, Rosana A.-
dc.contributor.authorBenito-León, Julián-
dc.contributor.authorRocón, Eduardo-
dc.date.issued2014-09-29-
dc.identifier.citationPLoS ONE 9(3):e93159 (2014)-
dc.identifier.urihttp://hdl.handle.net/10261/102634-
dc.description.abstractEssential tremor (ET) is characterised by postural and action tremors with a frequency of 4–12 Hz. Previous studies suggest that the tremor activity originates in the cerebello-thalamocortical pathways. Alprazolam is a short-acting benzodiazepine that attenuates tremors in ET. The mechanisms that mediate the therapeutic action of alprazolam are unknown; however, in healthy subjects, benzodiazepines increase cortical beta activity. In this study, we investigated the effect of alprazolam both on beta and tremor-related cortical activity and on alterations in tremor presentation in ET patients. Therefore, we characterised the dynamics of tremor and cortical activity in ET patients after alprazolam intake.es_ES
dc.description.sponsorshipThis work has been partially funded by CSIC, through the program for the incorporation of tenure researches CSIC-201050I040, “Development and clinical validation of a neuroprosthesis for tremor suppression”, and by the EU Commission through the grant EU-FP7-2011-287739, “NeuroTREMOR”. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.language.isoenges_ES
dc.relationEU/FP7/2011/287739es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectEssential tremores_ES
dc.subjectAlprazolam (benzodiazepine)es_ES
dc.subjectCortical activityes_ES
dc.titleEffects of Alprazolam on cortical activity and tremors in patients with essential tremores_ES
dc.typeartículoes_ES
dc.identifier.doi10.1371/journal.pone.0093159-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversion10.1371/journal.pone.0093159es_ES
dc.identifier.e-issn1932-6203-
dc.rights.license2014 Ibañez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es_ES
dc.contributor.funderEuropean Commissionen
dc.relation.csicSíes_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.pmid24667763-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.openairetypeartículo-
item.fulltextWith Fulltext-
item.languageiso639-1en-
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