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Título

Effect of dietary supplementation with flaxseed oil or vitamin E on sheep experimentally infected with Fasciola hepatica

Autor Martínez Pérez, José Manuel ; Robles Pérez, D. ; Benavides, Julio ; Morán, Lara ; Andrés, Sonia ; Giráldez, Francisco Javier ; Rojo Vázquez, Francisco Antonio ; Martínez Valladares, María
Palabras clave Vitamin E
Fasciola hepatica
Sheep
Immune system
Flaxseed oil
Fecha de publicación 2014
EditorElsevier
Citación Research in Veterinary Science 97: 71- 79 (2014)
ResumenThe effects of two diets supplemented with flaxseed oil (FO) or vitamin E (VE) were studied in sheep infected with Fasciola hepatica. The control group (CO), not supplemented, had higher weight gain and faecal egg count (P < 0.05) at the end of the study. At necropsy, the number (71.2 ± 26.5) and size of flukes were lower in the FO group (P < 0.01), probably due to the higher levels of white blood cells and lymphocytes (P < 0.01). This group also had higher red blood cell and haematocrit values (P < 0.01). The CO group had more severe hypoproteinaemia and hypoalbuminaemia, due to having the highest fluke burden (123.0 ± 35.2), and also the highest IgG1 titre (P < 0.01). The diet did not affect production or gene expression levels of IFN-γ and IL-4. On the other hand, the supplementation with VE led to a reduction in adult fluke burden (97.7 ± 39.9) and lower lipid oxidation in the liver (P < 0.001). © 2014 Elsevier Ltd.
Versión del editorhttp://dx.doi.org/10.1016/j.rvsc.2014.05.009
URI http://hdl.handle.net/10261/102482
DOI10.1016/j.rvsc.2014.05.009
ISSN0034-5288
E-ISSN1532-2661
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