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Zubiaur, Mercedes

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Firma en Digital.CSIC (*)
Zubiaur, Mercedes
 
Centro o Instituto
CSIC - Instituto de Parasitología y Biomedicina “López-Neyra” (IPBLN)
 
Especialización
I have a broad background in biochemistry, cellular-molecular biology, and immunology with specific training and skill to make connections across disciplines and to combine basic protein chemistry with biological signaling and protein interactions to study the functional relationship between the CD38 receptor, the TCR and protein kinases in the cellular behavior of T and B lymphocytes. I have long term research interests in the study of the molecular basis of alterations in the signaling of T and B lymphocytes in patients with autoimmune diseases, systemic lupus erythematosus or SLE, and psoriasis. In addition I studied CD38-deficient mice (Cd38KO) for phenotypic, functional and proteomic studies in animal models of autoimmune diseases (arthritis reumatoide and pristane induced-lupus). Several of these studies were carried out to search for potential biomarkers of the disease using proteomics approaches (2D-DiGE, MS-MALDI-TOF/TOF and LC MS/MS) and gene expression studies. Results of these researches have been presented in a number of national and international scientific meetings, and published in peer-reviewed publications of biochemistry, immunology, proteomic and dermatology journals. These results were the basis for doctoral thesis. In addition, as PI or co-Investigator on several funded grants I positively managed some projects and I collaborated with basic scientists [Dr. Jaime Sancho, IPBLN-CSIC; Dr. A. Corbí, CIB-CSIC; Dr. J. Abian CSIC-UAB; Dr. R. Merino, CSIC-UC; Dr. JA Barcenas, UCO; Dr. F. Malavasi and Dr. A. Funaro, Torino University; Dr. F. Lund, Alabama University; Dr. C. Terhorst, Harvard University] and clinical scientists [from University Hospitals, Granada, Dr. N. Ortego-Centeno and Dr. J. Salmeron].
 
Email
mzubiaur@ipb.csic.es
 
ORCID
 
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Publications

Refined By:
Autor:  Merino, Ramón

Resultados 1-5 de 5.

DerechosPreviewFecha Public.TítuloAutor(es)Tipo
1closedAccessaccesoRestringido.pdf.jpg2014Distinct serum proteome profiles associated with collagen-induced arthritis, and complete Freund's adjuvant-induced inflammation in CD38–/– miceRosal-Vela, Antonio; García-Rodríguez, Sonia ; Postigo, Jorge; Iglesias, Marcos CSIC; Merino, Jesús; Merino, Ramón CSIC ORCID; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID póster de congreso
2closedAccessaccesoRestringido.pdf.jpg2017CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven mechanismGarcía-Rodríguez, Sonia ; Rosal-Vela, Antonio; Zumaquero, Esther; Corbí, Angel L. ; Merino, Ramón CSIC ORCID; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID póster de congreso
3closedAccessaccesoRestringido.pdf.jpg9-feb-2022Cd38 deficiency ameliorates chronic graft versus Host disease murine lupus via a b-cell dependent mechanismLario-Simón, Antonio; Pérez-Sánchez-Cañete, María M.; Montosa, Laura; Guerrero-Fernández, Salvador; Longobardo, Victoria; Redondo-Sánchez, Sandra; Terrón-Camero, Laura Carmen CSIC ORCID; Andrés-León, Eduardo CSIC ORCID CVN ; Merino, Ramón CSIC ORCID; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID comunicación de congreso
4openAccessAnálisis de la expresión.pdf.jpgjun-2010Análisis de la expresión diferencial de proteínas en el suero de ratones C57BL/6 silvestres respecto a ratones C57BL/6 deficientes para CD38 en un modelo de artritis reumatoideRosal-Vela, Antonio; Postigo, Jorge; García-Rodríguez, Sonia ; Zumaquero, Esther; Longobardo, Victoria; Lario, Antonio; Navarro, P.; Merino, Ramón CSIC ORCID; Merino, Jesús; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID póster de congreso
5closedAccessaccesoRestringido.pdf.jpg20142D-DiGE/MS analysis allows the identification of a distinct serum protein profile in CD38-deficient mice associated with either collagen-induced arthritis or inflammationRosal-Vela, Antonio; García-Rodríguez, Sonia ; Postigo, Jorge; Merino, Jesús; Merino, Ramón CSIC ORCID; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID comunicación de congreso