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Zubiaur, Mercedes

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Firma en Digital.CSIC (*)
Zubiaur, Mercedes
 
Centro o Instituto
CSIC - Instituto de Parasitología y Biomedicina “López-Neyra” (IPBLN)
 
Especialización
I have a broad background in biochemistry, cellular-molecular biology, and immunology with specific training and skill to make connections across disciplines and to combine basic protein chemistry with biological signaling and protein interactions to study the functional relationship between the CD38 receptor, the TCR and protein kinases in the cellular behavior of T and B lymphocytes. I have long term research interests in the study of the molecular basis of alterations in the signaling of T and B lymphocytes in patients with autoimmune diseases, systemic lupus erythematosus or SLE, and psoriasis. In addition I studied CD38-deficient mice (Cd38KO) for phenotypic, functional and proteomic studies in animal models of autoimmune diseases (arthritis reumatoide and pristane induced-lupus). Several of these studies were carried out to search for potential biomarkers of the disease using proteomics approaches (2D-DiGE, MS-MALDI-TOF/TOF and LC MS/MS) and gene expression studies. Results of these researches have been presented in a number of national and international scientific meetings, and published in peer-reviewed publications of biochemistry, immunology, proteomic and dermatology journals. These results were the basis for doctoral thesis. In addition, as PI or co-Investigator on several funded grants I positively managed some projects and I collaborated with basic scientists [Dr. Jaime Sancho, IPBLN-CSIC; Dr. A. Corbí, CIB-CSIC; Dr. J. Abian CSIC-UAB; Dr. R. Merino, CSIC-UC; Dr. JA Barcenas, UCO; Dr. F. Malavasi and Dr. A. Funaro, Torino University; Dr. F. Lund, Alabama University; Dr. C. Terhorst, Harvard University] and clinical scientists [from University Hospitals, Granada, Dr. N. Ortego-Centeno and Dr. J. Salmeron].
 
Email
mzubiaur@ipb.csic.es
 
ORCID
 
Perfil en Google Scholar
 
WoS ResearcherID - Publons
 
Scopus AuthorID
 
Otros - ResearchGate
 
Otros identificadores (con url)
 

Publications

Results 1-20 of 27 (Search time: 0.048 seconds).

RightsPreviewIssue DateTitleAuthor(s)Type
1openAccessA novel isoform.pdf.jpg2011A novel isoform of the Ly108 gene ameliorates murine lupusKeszei, Marton; Detre, Cynthia; Rietdijk, Svend T.; Muñoz, P.; Romero, Xavier; Berger, Scott B.; Calpe, Silvia; Liao, Gongxian; Castro, Wilson; Aimee, Julien; Wu, Jing Y.; Shin, Dong M.; Sancho, Jaime CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID ; Morse, Herbert C.; Morel, Laurence; Engel, Pablo; Wang, Ninghai; Terhorst, Coxartículo
2openAccessAltered AKT1 and MAPK1.pdf.jpg2012Altered AKT1 and MAPK1 gene expression on peripheral blood mononuclear cells and correlation with T-helper-transcription factors in Systemic Lupus Erythematosus patientsGarcía-Rodríguez, Sonia ; Callejas-Rubio, J. L.; Ortego-Centeno, N.; Zumaquero, Esther; Ríos-Fernández, Raquel; Arias-Santiago, S.; Navarro, P.; Sancho, Jaime CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID artículo
3openAccessaccesoRestringido.pdf.jpg2008Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapseMuñoz, P.; Mittelbrunn, M.; Fuente, Hortensia de la; Pérez-Martínez, M.; García-Pérez, A.; Ariza-Veguillas, A.; Malavasi, F.; Zubiaur, Mercedes CSIC ORCID ; Sánchez-Madrid, Francisco; Sancho, Jaime CSIC ORCID artículo
4closedAccessaccesoRestringido.pdf.jpg2012Atheroma plaque, metabolic syndrome and inflammation in patients with psoriasisArias-Santiago, S.; Orgaz-Molina, J.; Castellote-Caballero, L.; Arrabal-Polo, M. A.; García-Rodríguez, Sonia ; Perandrés-López, R.; Ruiz, J. C.; Naranjo-Sintes, R.; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID ; Buendía-Eisman, A.artículo
5closedAccess2006CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunityMalavasi, F.; Deaglio, Silvia; Ferrero, E.; Funaro, Ada; Sancho, Jaime CSIC ORCID ; Ausiello, Clara M.; Ortolan, Erika; Vaisitti, Tiziana; Zubiaur, Mercedes CSIC ORCID ; Fedele, Giorgia; Aydin, S.; Tibaldi, Elena V.; Durelli, Ilaria; Lusso, Riccardo; Cozno, Franco; Horenstein Alberto L.artículo
6closedAccessaccesoRestringido.pdf.jpg2002CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-ζ immune receptor tyrosine-based activation motifsZubiaur, Mercedes CSIC ORCID ; Fernández, Olga; Ferrero, E.; Salmerón, J.; Malissen, B.; Malavasi, F.; Sancho, Jaime CSIC ORCID artículo
7closedAccessaccesoRestringido.pdf.jpg1997CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-ζ/ζ-associated protein-70 signaling pathways in Jurkat T lymphocytesZubiaur, Mercedes CSIC ORCID ; Izquierdo, Manuel CSIC ORCID ; Terhorst, Cox; Malavasi, F.; Sancho, Jaime CSIC ORCID artículo
8openAccesss41598-018-21337-6.pdf.jpg20-Feb-2018CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanismGarcía-Rodríguez, Sonia ; Rosal-Vela, Antonio; Botta, Davide; Cumba García, Luz M.; Zumaquero, Esther; Prados-Maniviesa, Verónica; Cerezo-Wallis, Daniela; Lo Buono, Nicola; Robles-Guirado, José-Ángel; Guerrero, Salvador; González-Paredes, Elena; Andrés-León, Eduardo CSIC ORCID CVN ; Corbí, Angel L. ; Mack, Matthias; Koch-Nolte, Friedrich; Merino, Ramón CSIC ORCID; Zubiaur, Mercedes CSIC ORCID ; Lund, Frances E.; Sancho, Jaime CSIC ORCID artículo
9closedAccessaccesoRestringido.pdf.jpg2003CD38 Signaling in T Cells Is Initiated within a Subset of Membrane Rafts Containing Lck and the CD3-ζ Subunit of the T Cell Antigen ReceptorMuñoz, P.; Navarro, M. D. C.; Pavón, Esther J.; Salmerón, J.; Malavasi, F.; Sancho, Jaime CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID artículo
10closedAccessaccesoRestringido.pdf.jpg1986Corticosteroidogenesis modulation by β-endorphin and dynorphin1-17 in isolated rat adrenocortical cellsGuaza, Carmen CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID ; Borrell, José CSICartículo
11closedAccessrestringido.pdf.jpg15-May-2006DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine productionCaparrós, Esther CSIC; Muñoz, Pilar; Sierra-Filardi, Elena CSIC ORCID ; Serrano-Gómez, Diego; Puig-Kröger, Amaya CSIC ORCID; Rodríguez-Fernández, José Luis CSIC ORCID ; Mellado, Mario CSIC ORCID ; Sancho, Jaime CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID ; Corbí, Angel L. artículo
12closedAccessaccesoRestringido.pdf.jpg2015Distinct serum proteome profiles associated with collagen-induced arthritis and complete Freund's adjuvant-induced inflammation in CD38-/- mice: The discriminative power of protein species or proteoformsRosal-Vela, Antonio; García-Rodríguez, Sonia ; Postigo, Jorge; Iglesias, Marcos CSIC; Longobardo, Victoria; Lario, Antonio; Merino, Jesús; Merino, Ramón CSIC ORCID; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID artículo
13closedAccessaccesoRestringido.pdf.jpg2010Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and LynZumaquero, Esther; Muñoz, P.; Cobo, Marién; Lucena, G.; Pavón, Esther J.; Martín, Ana Belén CSIC; Navarro, P.; García-Pérez, A.; Ariza-Veguillas, A.; Malavasi, F.; Sancho, Jaime CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID artículo
14openAccessExtracellular vesicles from pristane-treated CD38_Carrillo_PV_Art2022.pdf.jpg2022Extracellular vesicles from pristane-treated CD38-deficient mice express an antiinflammatory neutrophil protein signature, which reflects the mild lupus severity elicited in these miceCarrillo Rodríguez, Paula; Robles-Guirado, José-Ángel; Cruz-Palomares, Adrián; Palacios-Pedrero, Miguel-Ángel; González-Paredes, Elena; Más-Ciurana, Alex; Franco-Herrera, Carolina; Ruiz de Castroviejo Teba, Paloma A.; Lario, Antonio; Longobardo, Victoria; Montosa, Laura; Pérez-Sánchez-Cañete, María M.; Corzo Corbera, María-Mercedes; Redondo-Sánchez, Sandra; Jodar, Ana-Belén; Blanco, Francisco J. CSIC ; Zumaquero, Esther; Merino, Ramón CSIC ORCID; Sancho, Jaime CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID artículo
15openAccesss41598-017-16184-w.pdf.jpg21-Nov-2017Human canonical CD157/Bst1 is an alternatively spliced isoform masking a previously unidentified primate-specific exon included in a novel transcriptFerrero, E.; Lo Buono, Nicola; Morone, Simona; Parrotta, Rossella; Mancini, Cecilia; Brusco, Alfredo; Giacomino, Alice; Augeri, Stefania; Rosal-Vela, Antonio; García-Rodríguez, Sonia ; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID ; Fiorio Pla, Alessandra; Funaro, Adaartículo
16closedAccessaccesoRestringido.pdf.jpg2016Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38Rosal-Vela, Antonio; García-Rodríguez, Sonia ; Longobardo, Victoria; Postigo, Jorge; Iglesias, Marcos CSIC; Lario, Antonio; Merino, Jesús; Merino, Ramón CSIC ORCID; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID artículo
17closedAccessaccesoRestringido.pdf.jpg2006Increased association of CD38 with lipid rafts in T cells from patients with systemic lupus erythematosus and in activated normal T cellsPavón, Esther J.; Muñoz, P.; Navarro, M. D. C.; Raya-Álvarez, E.; Callejas-Rubio, J. L.; Navarro-Pelayo, F.; Ortego-Centeno, N.; Sancho, Jaime CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID artículo
18closedAccessaccesoRestringido.pdf.jpg2013Increased CD38 expression in T cells and circulating anti-CD38 IgG autoantibodies differentially correlate with distinct cytokine profiles and disease activity in systemic lupus erythematosus patientsPavón, Esther J.; Zumaquero, Esther; Rosal-Vela, Antonio; Khoo, K. M.; Cerezo-Wallis, Daniela; García-Rodríguez, Sonia ; Carrascal, Montserrat CSIC ORCID; Abián, Joaquín CSIC ORCID; Graeff, R.; Callejas-Rubio, J. L.; Ortego-Centeno, N.; Malavasi, F.; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID artículo
19closedAccessaccesoRestringido.pdf.jpg2012Increased expression and phosphorylation of the two S100A9 isoforms in mononuclear cells from patients with systemic lupus erythematosus: A proteomic signature for circulating low-density granulocytesPavón, Esther J.; García-Rodríguez, Sonia ; Zumaquero, Esther; Perandrés-López, R.; Rosal-Vela, Antonio; Lario, Antonio; Longobardo, Victoria; Carrascal, Montserrat CSIC ORCID; Abián, Joaquín CSIC ORCID; Callejas-Rubio, J. L.; Ortego-Centeno, N.; Zubiaur, Mercedes CSIC ORCID ; Sancho, Jaime CSIC ORCID artículo
20closedAccessaccesoRestringido.pdf.jpgFeb-2017Increased expression of microRNA-155 in peripheral blood mononuclear cells from psoriasis patients is related to disease activityGarcía-Rodríguez, Sonia ; Arias-Santiago, S.; Blasco-Morente, G; Orgaz-Molina, J.; Rosal-Vela, Antonio; Navarro, P.; Magro-Checa, Cesar; Martinez-Lopez, A.; Ruiz, J. C.; Raya, Enrique; Naranjo-Sintes, R.; Sancho, Jaime CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID artículo