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1openAccess21 J Extrac Ves Fabry.pdf.jpg12-mar-2021Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disordersSeras‐Franzoso, Joaquin; Díaz‐Riascos, Zamira V.; Corchero, José Luis; González, Patricia; García-Aranda, Natalia; Mandaña, Mònica; Riera, Roger; Boullosa, Ana; Mancila, Sandra; Grayston, Alba; Moltó-Abad, Marc; Mendoza, Rosa; Garcia‐Fruitós, Elena; Pintos‐Morell, Guillem; Albertazzi, Lorenzo; Rosell, Anna; Casas, Josefina CSIC ORCID ; Villaverde, Antonio; Schwartz Jr., Simó; Abasolo, Ibaneartículo
2openAccess1-s2.0-S2213231721002111-main.pdf.jpgsep-2021Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulationTorres, Sandra CSIC ORCID; Solsona-Vilarrasa, Estel CSIC ORCID; Nuñez, Susana CSIC; Matías, Nuria CSIC; Insausti, Naroa CSIC ORCID; Castro, Fernanda; Casasempere, Mireia; Fabriàs, Gemma CSIC ORCID ; Casas, Josefina CSIC ORCID ; Enrich, Carlos; Fernández-Checa, José C. CSIC ORCID; García-Ruiz, Carmen CSIC ORCID artículo
3openAccessbph.15377.pdf.jpg12-feb-2021Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional statusMiralpeix, Cristina; Reguera, Ana Cristina; Fosch, Anna; Casas, Maria; Lillo, Jaume; Navarro, Gemma; Franco, Rafael; Casas, Josefina CSIC ORCID ; Alexander, Stephen P.H.; Casals, Núria; Rodríguez‐Rodríguez, Rosalíaartículo
4openAccess1-s2.0-S1063458421008074-main.pdf.jpgsep-2021Inhibition of sphingosine 1-phosphate protects mice against chondrocyte catabolism and osteoarthritisCherifi, C.; Latourte, A.; Vettorazzi, S.; Tuckermann, J.; Provot, S.; Ea, H.-K.; Ledoux, A.; Casas, Josefina CSIC ORCID ; Cuvillier, O.; Richette, P.; Ostertag, A.; Cohen-Solal, M.; Hay, E.artículo
5openAccessThe anti cancer drug ABTL0812 induces ER stress mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.pdf.jpg13-may-2020The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.Muñoz-Guardiola, Pau; Casas, Josefina CSIC ORCID ; Megías-Roda, Elisabet; Solé, Sonia; Perez-Montoyo, Héctor; Yeste-Velasco, Marc; Erazo, Tatiana; Dièguez-Martínez, Nora; Espinosa-Gil, Sergio; Muñoz-Pinedo, Cristina; Yoldi, Guillermo; Abad, José Luis CSIC ORCID ; Segura, Miguel F.; Moran, Teresa; Romeo, Margarita; Bosch-Barrera, Joaquim; Oaknin, Ana; Alfón, Jose; Domènech, Carles; Fabriàs, Gemma CSIC ORCID ; Velasco, Guillermo; Lizcano, José M.artículo
6openAccessadvs.202003468.pdf.jpg3-feb-2021Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV‐1 Env ClusteringNieto-Garai, Jon Ander CSIC ORCID; Arboleya, Aroa CSIC; Otaegi, Sara; Chojnacki, Jakub; Casas, Josefina CSIC ORCID ; Fabriàs, Gemma CSIC ORCID ; Contreras, F. Xabier CSIC ORCID; Kräusslich, Hans‐Georg; Lorizate, Maier CSIC ORCIDartículo
7openAccessMicrobBiotech2020-Randez.pdf.jpg25-mar-2020Myriocin‐induced adaptive laboratory evolution of an industrial strain of Saccharomyces cerevisiae reveals its potential to remodel lipid composition and heat toleranceRández Gil, Francisca CSIC ORCID; Prieto Alamán, José Antonio CSIC ORCID; Rodríguez Puchades, Alejandro; Casas, Josefina CSIC ORCID ; Sentandreu, Vicente; Estruch, Franciscoartículo
8openAccess2020 The Febs J Hurtado et al.pdf.jpg20-jun-2020HDAC11 is a novel regulator of fatty acid oxidative metabolism in skeletal muscleHurtado, Erica; Núñez‐Álvarez, Yaiza; Gutiérrez‐Caballero, Cristina; Muñoz, Mar; Casas, Josefina CSIC ORCID ; Pendás, Alberto M. CSIC ORCID ; Peinado, Miguel A.; Suelves, Mònicaartículo
9closedAccessaccesoRestringido.pdf.jpg2021Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Klionsky, Daniel J.; Alonso, Alicia CSIC ORCID; Hervás, Javier H. CSIC ORCID; Arévalo, María Ángeles CSIC ORCID ; García-Sanz, Patricia CSIC ORCID; Belló Pérez, Melissa; García del Portillo, Francisco CSIC ORCID ; Boya, Patricia CSIC ORCID ; Pinar, Mario CSIC ORCID ; Testillano, Pilar S. CSIC ORCID ; Casas, Josefina CSIC ORCID ; Colell Riera, Anna CSIC ORCID; Fernández-Checa, José C. CSIC ORCID; Moles, Anna CSIC ORCID; Coll, Núria S. CSIC ORCID; Crespo, José L. CSIC ORCID ; Ruano, Diego CSIC ORCID; Lastres-Becker, Isabel CSIC ORCID; Vincent, Olivier CSIC ORCID ; Martín-Sanz, Paloma CSIC ORCID ; Valverde, Ángela M. CSIC ORCID ; Varela-Nieto, Isabel CSIC ORCID ; Gargini, Ricardo CSIC ORCID; Izquierdo, José M. CSIC ORCID ; López-Guerrero, José Antonio CSIC ORCID; Wandosell, Francisco CSIC ORCID ; Romero, Luis; Sanz, Pascual CSIC ORCID ; Vilar, Marçal CSIC ORCID ; Pimentel-Muiños, Felipe X. CSIC ORCID ; Sánchez-Alcázar, José Antonio CSIC ORCID ; Figueras Huerta, Antonio CSIC ORCID artículo
10openAccessA Mechanism-Based Sphingosine-1-phosphate Lyase Inhibitor.pdf.jpg17-ene-2020A Mechanism-Based Sphingosine-1-phosphate Lyase InhibitorPons, Guillem; Riba, Daniel; Casasampere, Mireia CSIC ORCID; Izquierdo, Eduardo; Abad, José Luis CSIC ORCID ; Fabriàs, Gemma CSIC ORCID ; Rodríguez Ortega, Pilar G.; Montejo, Manuel; López González, Juan J.; Casas, Josefina CSIC ORCID ; Delgado Cirilo, Antonio CSIC ORCIDartículo
11openAccessd1ob00113b.pdf.jpg23-feb-2021Synthesis and characterization of bichromophoric 1-deoxyceramides as FRET probesIzquierdo, Eduardo; Casasampere, Mireia CSIC ORCID; Fabriàs, Gemma CSIC ORCID ; Abad, José Luis CSIC ORCID ; Casas, Josefina CSIC ORCID ; Delgado Cirilo, Antonio CSIC ORCIDartículo
12openAccess#EJMC_revised final UNmarked.pdf.jpg24-feb-2021Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cellsBielsa, Núria; Casasampere, Mireia CSIC ORCID; Aseeri, Mazen; Casas, Josefina CSIC ORCID ; Delgado Cirilo, Antonio CSIC ORCID; Abad, José Luis CSIC ORCID ; Fabriàs, Gemma CSIC ORCID artículo
13openAccess20 Brain A Pujol peer review.pdf.jpg21-ago-2020Expanding the clinical and genetic spectrum of PCYT2-related disordersVélez-Santamaría, Valentina; Ventura, Edgar; Macmurdo, Colleen; Planas-Serra, Laura; Schlüter, Agatha; Casas, Josefina CSIC ORCID ; Martínez, Juan José; Casasnovas, Carlos; Si, Yue; Thompson, Stephanie S.; Maroofian, Reza; Pujol, Auroraartículo
14openAccess20 biomolecules 10 1471 V Llorente.pdf.jpg22-sep-2020Biophysical and Lipidomic Biomarkers of Cardiac Remodeling Post-Myocardial Infarction in HumansSamouillan, Valerie; Martinez de Lejarza Samper, Ignacio Miguel; Benitez-Amaro, Aleyda CSIC ORCID; Vilades, David; Dandurand, Jany; Casas, Josefina CSIC ORCID ; Jorge, Esther; Gonzalo-Calvo, David de CSIC ORCID; Gallardo, Alberto; Lerma, Enrique; Guerra Ramos, José María; Carreras, Francesc; Leta, Rubén; Llorente-Cortés, Vicenta CSIC ORCIDartículo
15openAccessVanSantenHM_CCR5deficiency.pdf.jpg11-jun-2020CCR5 deficiency impairs CD4+ T-cell memory responses and antigenic sensitivity through increased ceramide synthesisMartín-Leal, Ana; Blanco, Raquel; Casas, Josefina CSIC ORCID ; Sáez, María Eugenia; Rodríguez-Bovolenta, Elena; de Rojas, Itziar; Drechsler, Carina; Real, Luis M.; Fabriàs, Gemma CSIC ORCID ; Ruíz, Agustín; Castro, Mario; Schamel, Wolfgang W.A.; Alarcón, Balbino CSIC ORCID; Van Santen, Hisse M; Mañes, Santosartículo
16openAccessijms-22-10907-v2.pdf.jpg9-oct-2021Diets with Higher ω-6/ω-3 Ratios Show Differences in Ceramides and Fatty Acid Levels Accompanied by Increased Amyloid-Beta in the Brains of Male APP/PS1 Transgenic MiceOrdóñez-Gutiérrez, Lara CSIC ORCID; Fabriàs, Gemma CSIC ORCID ; Casas, Josefina CSIC ORCID ; Wandosell, Francisco CSIC ORCID artículo
17openAccessLedesmaMD_InhibitionofFattyAcid.pdf.jpg14-sep-2020Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signalingBartoll, Adrián CSIC; Toledano-Zaragoza, Ana; Casas, Josefina CSIC ORCID ; Guzmán, Manuel; Schchman, Edward H; Ledesma, M. Dolores CSIC ORCIDartículo
18openAccessfj.202000678R.pdf.jpg15-jul-2020Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLDWeber, Minéia; Mera, Paula; Casas, Josefina CSIC ORCID ; Salvador, Javier; Rodríguez, Amaia; Alonso, Sergio; Sebastián, David; Soler‐Vázquez, M. Carmen; Montironi, Carla; Recalde, Sandra; Fucho, Raquel CSIC ORCID; Calderón‐Domínguez, María; Mir, Joan Francesc; Bartrons, Ramón; Escolà-Gil, Joan Carles; Sánchez‐Infantes, David; Zorzano, Antonio; Llorente-Cortés, Vicenta CSIC ORCID; Casals, Núria; Valentí, Víctor; Frühbeck, Gema; Herrero, Laura CSIC ORCID; Serra, Dolorsartículo
19openAccessCCR5 deficiency impairs CD4+ T-cell memory.pdf.jpg11-jun-2020CCR 5 deficiency impairs CD 4+ T‐cell memory responses and antigenic sensitivity through increased ceramide synthesisMartín‐Leal, Ana; Blanco, Raquel; Casas, Josefina CSIC ORCID ; Sáez, María Eugenia; Rodríguez‐Bovolenta, Elena; de Rojas, Itziar; Drechsler, Carina; Real, Luis Miguel CSIC ORCID; Fabriàs, Gemma CSIC ORCID ; Ruíz, Agustín; Castro, Mario; Schame, Wolfgang WA; Alarcón, Balbino CSIC ORCID; Van Santen, Hisse M; Mañes, Santosartículo
20openAccessd0sc03166f.pdf.jpg22-oct-2020Click and Count: Specific Detection of Acid Ceramidase Activity in Live CellsCasasampere, Mireia CSIC ORCID; Izquierdo, Eduardo; Casas, Josefina CSIC ORCID ; Abad, José Luis CSIC ORCID ; Liu, Xiao; Xu, Ruijuan; Mao, Cungui; Chang, Young-Tae; Delgado Cirilo, Antonio CSIC ORCID; Fabriàs, Gemma CSIC ORCID artículo
21openAccess231457_1_merged_1594821670.pdf.jpgnov-2020β-Galactosylceramidase Promotes Melanoma Growth via Modulation of Ceramide MetabolismBelleri, Mirella; Paganini, Giuseppe; Coltrini, Daniela; Zizioli, Daniela; Ronca, Roberto; Corsini, Michela; Barbieri, Andrea; Grillo, Elisabetta; Calza, Stefano; Bresciani, Roberto; Maiorano, Eugenio; Mastropasqua, Mauro G.; Annese, Tiziana; Giacomini, Arianna; Ribatti, Domenico; Casas, Josefina CSIC ORCID ; Levade, Thierry; Fabriàs, Gemma CSIC ORCID ; Presta, Marcoartículo
22openAccess1-s2.0-S0960076020302557-main.pdf.jpgsep-2020Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunctionMaharaj, A.; Williams, J.; Bradshaw, T.; Güran, T.; Braslavsky, D.; Casas, Josefina CSIC ORCID ; Chan, L. F.; Metherell, M. A.; Prasad, R.artículo
23openAccessWandosellF_DietswithHigher !-6-!-3Ratios.pdf.jpg9-oct-2021Diets with higher ω-6/ω-3 ratios show differences in ceramides and fatty acid levels accompanied by increased amyloid-beta in the brains of male APP/PS1 transgenic miceOrdóñez-Gutiérrez, Lara CSIC ORCID; Fabriàs, Gemma CSIC ORCID ; Casas, Josefina CSIC ORCID ; Wandosell, Francisco CSIC ORCID artículo
24openAccessemmm.201911776.pdf.jpg2020Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling.Bartoll, Adrián CSIC; Toledano‐Zaragoza, Ana; Casas, Josefina CSIC ORCID ; Guzmán, Manuel; Schuchman, Edward H.; Ledesma, M. Dolores CSIC ORCIDartículo
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