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Título: | EGFR-dependent downregulation of Capicua and the establishment of Drosophila dorsoventral polarity |
Autor: | Andreu, María José CSIC; Ajuria, Leiore CSIC ORCID; Samper, Núria CSIC ORCID ; Campuzano, Sonsoles CSIC ORCID; González-Crespo, Sergio CSIC ORCID ; Jiménez, Gerardo CSIC ORCID | Palabras clave: | Drosophila EGFR signaling Follicle cells Oogenesis Capicua Dorsoventral patterning |
Fecha de publicación: | 2012 | Editor: | Landes Bioscience | Citación: | Fly 6(4): 234-239 (2012) | Resumen: | Dorsoventral (DV) axis formation in Drosophila begins during oogenesis through the graded activation of the EGF receptor (EGFR)-Ras-MAPK signaling pathway in the follicle cell layer of the egg chamber. EGFR signaling, which is higher in dorsal follicle cells, represses expression of the sulfotransferase-encoding gene pipe, thereby delimiting a ventral domain of Pipe activity that is critical for the subsequent induction of ventral embryonic fates. We have characterized the transcriptional circuit that links EGFR signaling to pipe repression: in dorsal follicle cells, the homeodomain transcription factor Mirror (Mirr), which is induced by EGFR signaling, directly represses pipe transcription, whereas in ventral follicle cells, the HMG-box protein Capicua (Cic) supports pipe expression by repressing mirr. Although Cic is under negative post-transcriptional regulation by Ras-MAPK signaling in different contexts, the relevance of this mechanism for the interpretation of the EGFR signal during DV pattern formation remains unclear. Here, we consider a model where EGFR-mediated downregulation of Cic modulates the spatial distribution of Mirr protein in lateral follicle cells, thereby contributing to define the position at which the pipe expression border is formed. © 2012 Landes Bioscience. | URI: | http://hdl.handle.net/10261/87860 | DOI: | 10.4161/fly.21160 | Identificadores: | doi: 10.4161/fly.21160 issn: 1933-6934 e-issn: 1933-6942 |
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