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Título: | Apaf1 plays a pro-survival role by regulating centrosome morphology and function |
Autor: | Ferraro, Elisabetta; Pesaresi, Maria Grazia; De Zio, Daniela; Cencioni, Maria Teresa; Gortat, Anna; Cozzolino, Mauro; Berghella, Libera; Salvatore, Anna Maria; Oettinghaus, Bjorn; Scorrano, Luca; Pérez-Payá, Enrique CSIC; Cecconi, Francesco | Palabras clave: | Apaf-1 Centrosomes Microtubules |
Fecha de publicación: | 7-oct-2011 | Editor: | Company of Biologists | Citación: | Journal of Cell Science 124(Pt 20): 3450-63 (2011 Oct 15) | Resumen: | The apoptotic protease activating factor 1 (Apaf1) is the main component of the apoptosome, and a crucial factor in the mitochondria-dependent death pathway. Here we show that Apaf1 plays a role in regulating centrosome maturation. By analyzing Apaf1-depleted cells, we have found that Apaf1 loss induces centrosome defects that impair centrosomal microtubule nucleation and cytoskeleton organization. This, in turn, affects several cellular processes such as mitotic spindle formation, cell migration and mitochondrial network regulation. As a consequence, Apaf1-depleted cells are more fragile and have a lower threshold to stress than wild-type cells. In fact, we found that they exhibit low Bcl-2 and Bcl-X(L) expression and, under apoptotic treatment, rapidly release cytochrome c. We also show that Apaf1 acts by regulating the recruitment of HCA66, with which it interacts, to the centrosome. This function of Apaf1 is carried out during the cell life and is not related to its apoptotic role. Therefore, Apaf1 might also be considered a pro-survival molecule, whose absence impairs cell performance and causes a higher responsiveness to stressful conditions | Descripción: | 14 páginas, 10 figuras. PMID:21984814[PubMed] | Versión del editor: | http://dx.doi.org/10.1242/jcs.086298 | URI: | http://hdl.handle.net/10261/48368 | DOI: | 10.1242/jcs.086298 | ISSN: | 0021-9533 | E-ISSN: | 1477-9137 |
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J Cell Sci 2011-124-03450.pdf | 9,11 MB | Adobe PDF | Visualizar/Abrir |
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