Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37870
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Título : Enantioselective synthesis of cis-α-substituted cycloalkanols and trans-cycloalkyl amines thereof
Autor : Fernández, Rosario, Ros, Abel, Magriz, Antonio, Dietrich, Hansjörg, Lassaletta, José M.
Palabras clave : Asymmetric catalysis
Amines
Transfer hydrogenation
Dynamic kinetic resolution
Fecha de publicación : 7-May-2007
Editor: Elsevier
Resumen: The diastereo- and enantioselective syntheses of trans-cycloalkyl amines was accomplished through a three-step sequence consisting of: (1) asymmetric transfer hydrogenation through dynamic kinetic resolution of bicyclic and monocyclic α-substituted ketones using HCO2H/Et3N as the hydrogen source and TsDPEN-based Ru(II) catalysts, (2) nucleophilic hydroxyl to azide substitution of the resulting cis-cycloalkanols using diphenyl phosphoryl azide under modified Mitsunobu conditions, and (3) reduction of the trans-azide intermediates with LiAlH4 of PPh3/H2O to the desired targets.
Descripción : 9 páginas, 1 figura, 2 tablas, 6 esquemas.
Versión del editor: http://dx.doi.org/10.1016/j.tet.2007.04.075
URI : http://hdl.handle.net/10261/37870
ISSN: 0040-4020
DOI: 10.1016/j.tet.2007.04.075
Citación : Tetrahedron 63(29): 6755-6763 (2007)
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