Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/354789
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Female Infertility Is Associated with an Altered Expression Profile of Different Members of the Tachykinin Family in Human Granulosa Cells |
Autor: | Blasco, Víctor; Pinto, Francisco M; Fernández-Atucha, Ainhoa; Dodd, Nicolás Prados; Fernández-Sánchez, Manuel; Candenas, Luz | Palabras clave: | Advanced maternal age Endometriosis Human granulosa cells Polycystic ovarian syndrome Tachykinins |
Fecha de publicación: | ene-2023 | Editor: | Springer | Citación: | Reproductive Sciences 30:258–269, (2023) | Resumen: | Neurokinin B (NKB) and its cognate receptor, NK3R, play a key role in the regulation of reproduction. NKB belongs to the family of tachykinins, which also includes substance P and neurokinin A, both encoded by the by the gene TAC1, and hemokinin-1, encoded by the TAC4 gene. In addition to NK3R, tachykinin effects are mediated by NK1R and NK2R, encoded by the genes TACR1 and TACR2, respectively. The role of these other tachykinins and receptors in the regulation of women infertility is mainly unknown. We have analyzed the expression profile of TAC1, TAC4, TACR1, and TACR2 in mural granulosa and cumulus cells from women presenting different infertility etiologies, including polycystic ovarian syndrome, advanced maternal age, low ovarian response, and endometriosis. We also studied the expression of MME, the gene encoding neprilysin, the most important enzyme involved in tachykinin degradation. Our data show that TAC1, TAC4, TACR1, TACR2, and MME expression is dysregulated in a different manner depending on the etiology of women infertility. The abnormal expression of these tachykinins and their receptors might be involved in the decreased fertility of these patients, offering a new insight regarding the diagnosis and treatment of women infertility. | Versión del editor: | https://link.springer.com/article/10.1007/s43032-022-00998-9 | URI: | http://hdl.handle.net/10261/354789 | DOI: | 10.1007/s43032-022-00998-9 | ISSN: | 1933-7191 |
Aparece en las colecciones: | (IIQ) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Blasco23_Female Infertility Is Associated with an Altered Expression Profile of Different Members of.pdf | Artículo Principal | 788,09 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
4
checked on 01-may-2024
Page view(s)
4
checked on 03-may-2024
Download(s)
5
checked on 03-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons