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Título: | Antiparasitic activities of compounds isolated from Aspergillus fumigatus strain discovered in northcentral Nigeria |
Autor: | Diyaolu, O. A.; Preet, G.; Fagbemi, A. A.; Annang, F.; Pérez-Moreno, Guiomar; Bosch-Navarrete, Cristina; Adebisi, O. O.; Oluwabusola, E. T.; Milne, Bruce F.; Jaspars, Marcel; Ebel, Rainer | Palabras clave: | Aspergillus fumigatus OSMAC Metabolomics Molecular docking Antitrypanosomal Antiplasmodial In silico molecular docking |
Fecha de publicación: | 6-ene-2023 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Antibiotics 12: 109 (2023) | Resumen: | In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds. | Versión del editor: | http://dx.doi.org/10.3390/antibiotics12010109 | URI: | http://hdl.handle.net/10261/349057 | Identificadores: | doi: 10.3390/antibiotics12010109 issn: 2079-6382 |
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