Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/349057
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Diyaolu, O. A. | es_ES |
dc.contributor.author | Preet, G. | es_ES |
dc.contributor.author | Fagbemi, A. A. | es_ES |
dc.contributor.author | Annang, F. | es_ES |
dc.contributor.author | Pérez-Moreno, Guiomar | es_ES |
dc.contributor.author | Bosch-Navarrete, Cristina | es_ES |
dc.contributor.author | Adebisi, O. O. | es_ES |
dc.contributor.author | Oluwabusola, E. T. | es_ES |
dc.contributor.author | Milne, Bruce F. | es_ES |
dc.contributor.author | Jaspars, Marcel | es_ES |
dc.contributor.author | Ebel, Rainer | es_ES |
dc.date.accessioned | 2024-03-04T09:50:04Z | - |
dc.date.available | 2024-03-04T09:50:04Z | - |
dc.date.issued | 2023-01-06 | - |
dc.identifier | doi: 10.3390/antibiotics12010109 | - |
dc.identifier | issn: 2079-6382 | - |
dc.identifier.citation | Antibiotics 12: 109 (2023) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/349057 | - |
dc.description.abstract | In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds. | es_ES |
dc.description.sponsorship | The Schlumberger Foundation Faculty for the Future Scholarship Program funded this research and the article processing charge. B.F.M. acknowledges national funds from the Portuguese FCT–Fundação para a Ciência e a Tecnologia, I.P., within the projects UIDB/04564/2020 and UIDP/04564/2020. | es_ES |
dc.format | application/pdf | es_ES |
dc.language | eng | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Aspergillus fumigatus | es_ES |
dc.subject | OSMAC | es_ES |
dc.subject | Metabolomics | es_ES |
dc.subject | Molecular docking | es_ES |
dc.subject | Antitrypanosomal | es_ES |
dc.subject | Antiplasmodial | es_ES |
dc.subject | In silico molecular docking | es_ES |
dc.title | Antiparasitic activities of compounds isolated from Aspergillus fumigatus strain discovered in northcentral Nigeria | es_ES |
dc.type | artículo | es_ES |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3390/antibiotics12010109 | es_ES |
dc.date.updated | 2024-03-04T09:50:05Z | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Schlumberger Foundation | es_ES |
dc.contributor.funder | Fundação para a Ciência e a Tecnologia (Portugal) | es_ES |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001871 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100002322 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (IPBLN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2023_A_Diyaolu.pdf | 3,69 MB | Unknown | Visualizar/Abrir |
CORE Recommender
Este item está licenciado bajo una Licencia Creative Commons