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Título: | AG5 is a potent non-steroidal anti-inflammatory and immune regulator that preserves innate immunity |
Autor: | Botella Asunción, Pablo CSIC ORCID ; Rivero-Buceta, Eva CSIC ORCID; Vidaurre-Agut, Carla CSIC ORCID; Lama, Raquel CSIC ORCID CVN; Rey-Campos, Magalí CSIC ORCID; Moreno, Alejandro; Mendoza, Laura; Mingo-Casas, Patricia; Escribano-Romero, Estela; Gutiérrez-Adán, Alfonso CSIC ORCID ; Saiz, Juan Carllos; Smerdou, Cristian; González, Gloria; Prósper, Felipe Luis; Argemí, Josep María; San Miguel, Jesús; Sánchez-Cordón, Pedro J.; Figueras Huerta, Antonio CSIC ORCID ; Quesada-Gómez, José Manuel; Novoa, Beatriz CSIC ORCID; Montoya, María CSIC ORCID ; Martín-Acebes, Miguel A.; Pineda-Lucena, Antonio CSIC ORCID; Benlloch Baviera, José María CSIC ORCID | Palabras clave: | Inflammation Cytokine storm COVID-19 Andrographolide Dexamethason Innate immunity |
Fecha de publicación: | 2023 | Editor: | Elsevier | Citación: | Biomedicine and Pharmacotherapy 169: 115882 (2023) | Resumen: | An archetypal anti-inflammatory compound against cytokine storm would inhibit it without suppressing the innate immune response. AG5, an anti-inflammatory compound, has been developed as synthetic derivative of andrographolide, which is highly absorbable and presents low toxicity. We found that the mechanism of action of AG5 is through the inhibition of caspase-1. Interestingly, we show with in vitro generated human monocyte derived dendritic cells that AG5 preserves innate immune response. AG5 minimizes inflammatory response in a mouse model of lipopolysaccharide (LPS)-induced lung injury and exhibits in vivo anti-inflammatory efficacy in the SARS-CoV-2-infected mouse model. AG5 opens up a new class of anti-inflammatories, since contrary to NSAIDs, AG5 is able to inhibit the cytokine storm, like dexamethasone, but, unlike corticosteroids, preserves adequately the innate immunity. This is critical at the early stages of any naïve infection, but particularly in SARS-CoV-2 infections. Furthermore, AG5 showed interesting antiviral activity against SARS-CoV-2 in humanized mice | Descripción: | 12 pages, 5 figures.-- This is an open access article under the CC BY-NC-ND license | Versión del editor: | https://doi.org/10.1016/j.biopha.2023.115882 | URI: | http://hdl.handle.net/10261/341425 | DOI: | 10.1016/j.biopha.2023.115882 | ISSN: | 0753-3322 |
Aparece en las colecciones: | (IIM) Artículos (INIA) Artículos (PTI Salud Global) Colección Especial COVID-19 |
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AG5_potent_nonsteroidal_OA_2023.pdf | 7,15 MB | Adobe PDF | Visualizar/Abrir | |
1-s2.0-S0753332223016803-mmc1.docx | 263,88 kB | Microsoft Word XML | Visualizar/Abrir |
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