Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/330229
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Rodríguez Pulido, Miguel Ramón | es_ES |
dc.contributor.author | Calvo Pinilla, Eva María | es_ES |
dc.contributor.author | Polo, Miryam | es_ES |
dc.contributor.author | Saiz Calahorra, Juan Carlos | es_ES |
dc.contributor.author | Fernández González, Raúl | es_ES |
dc.contributor.author | Pericuesta Camacho, Eva | es_ES |
dc.contributor.author | Gutiérrez-Adán, Alfonso | es_ES |
dc.contributor.author | Sobrino Castelló, Francisco | es_ES |
dc.contributor.author | Martín-Acebes, M. A. | es_ES |
dc.contributor.author | Sáiz, Margarita | es_ES |
dc.date.accessioned | 2023-07-03T09:13:48Z | - |
dc.date.available | 2023-07-03T09:13:48Z | - |
dc.date.issued | 2023-03-29 | - |
dc.identifier.citation | Frontiers in Immunology 14: e1166725 (2023) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/330229 | - |
dc.description | 12 Pág. | es_ES |
dc.description.abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of a potentially severe respiratory disease, the coronavirus disease 2019 (COVID-19), an ongoing pandemic with limited therapeutic options. Here, we assessed the anti-coronavirus activity of synthetic RNAs mimicking specific domains in the non-coding regions of the foot-and-mouth disease virus (FMDV) genome (ncRNAs). These molecules are known to exert broad-spectrum antiviral activity in cell culture, mice and pigs effectively triggering the host innate immune response. The ncRNAs showed potent antiviral activity against SARS-CoV-2 after transfection in human intestinal Caco-2 and lung epithelium Calu-3 2B4 cells. When the in vivo efficacy of the FMDV ncRNAs was assessed in K18-hACE2 mice, administration of naked ncRNA before intranasal SARS-CoV-2 infection significantly decreased the viral load and the levels of pro-inflammatory cytokines in the lungs compared with untreated infected mice. The ncRNAs were also highly efficacious when assayed against common human HCoV-229E and porcine transmissible gastroenteritis virus (TGEV) in hepatocyte-derived Huh-7 and swine testis ST cells, respectively. These results are a proof of concept of the pan-coronavirus antiviral activity of the FMDV ncRNAs including human and animal divergent coronaviruses and potentially enhance our ability to fight future emerging variants. | es_ES |
dc.description.sponsorship | This research work was funded by the European Commission – NextGenerationEU (Regulation EU 2020/2094), through CSIC´s Global Health Platform (PTI Salud Global), grants SGL 2103051 (to MS and FS) and SGL2103053 (to MM-A). It was further supported by the Spanish Ministry of Science and Innovation, grant PID2020-113184RB-C21 (to FS and MS) and by grant S018/BAA-4370 (co-financed by the Autonomous Community of Madrid and EC FEDER funds, to FS). MP was the recipient of a scholarship from the CSIC´s JAE Intro program. | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC//SGL 2103051 | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113184RB-C21/ES/VACUNAS PEPTIDICAS, ESTRATEGIAS ANTIVIRALES Y MECANISMOS DE EVASION INMUNE. APLICACIONES BIOTERAPEUTICAS/ | es_ES |
dc.relation | S018/BAA-4370 | es_ES |
dc.relation.ispartof | Frontiers in immunology | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | COVID-19 | es_ES |
dc.subject | RNA-based therapy | es_ES |
dc.subject | SARS-CoV-2 | es_ES |
dc.subject | Antiviral immunity | es_ES |
dc.subject | Coronaviruses | es_ES |
dc.subject | Foot-and-mouth disease virus (FMDV) | es_ES |
dc.subject | Non-coding RNA | es_ES |
dc.subject | Type-I IFN | es_ES |
dc.title | Non-coding RNAs derived from the foot-and-mouth disease virus genome trigger broad antiviral activity against coronaviruses | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.3389/fimmu.2023.1166725 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fimmu.2023.1166725 | es_ES |
dc.identifier.e-issn | 1664-3224 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.contributor.orcid | Rodríguez Pulido, Miguel Ramón [0000-0003-2101-8974] | es_ES |
dc.contributor.orcid | Calvo Pinilla, Eva María [0000-0002-4667-4081] | es_ES |
dc.contributor.orcid | Polo, Miryam [0000-0002-5222-2313] | es_ES |
dc.contributor.orcid | Saiz Calahorra, Juan Carlos [0000-0001-8269-5544] | es_ES |
dc.contributor.orcid | Fernández González, Raúl [0000-0003-1989-2945] | es_ES |
dc.contributor.orcid | Pericuesta Camacho, Eva [0000-0001-9387-3270] | es_ES |
dc.contributor.orcid | Gutiérrez-Adán, Alfonso [0000-0001-9893-9179] | es_ES |
dc.contributor.orcid | Sobrino, F. [0000-0003-4968-8291] | es_ES |
dc.contributor.orcid | Martín-Acebes, M. A. [0000-0001-6015-3613] | es_ES |
dc.contributor.orcid | Sáiz, Margarita [0000-0003-3893-7926] | es_ES |
dc.identifier.pmid | 37063925 | - |
dc.identifier.scopus | 2-s2.0-85152628012 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85152628012 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Aparece en las colecciones: | (INIA) Artículos (PTI Salud Global) Colección Especial COVID-19 (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Non_coding_RNAs_derived_from.pdf | artículo | 5,54 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
1
checked on 16-may-2024
SCOPUSTM
Citations
3
checked on 18-may-2024
WEB OF SCIENCETM
Citations
2
checked on 24-feb-2024
Page view(s)
38
checked on 23-may-2024
Download(s)
25
checked on 23-may-2024