Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/32365
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A molecular role for lysyl oxidase-like 2 enzyme in Snail regulation and tumor progression |
Autor: | Peinado, Héctor; Iglesias de la Cruz, Carmen; Olmeda, David CSIC ORCID; Vega de los Reyes, Sonia CSIC ORCID; Nieto, M. Ángela CSIC ORCID ; Cano, Amparo CSIC; García del Portillo, Francisco CSIC ORCID | Palabras clave: | E-cadherin EMT LOXL Snail Tumor progression |
Fecha de publicación: | 2005 | Editor: | Nature Publishing Group | Citación: | Embo Journal 24(19): 3446-3458 (2005) | Resumen: | The transcription factor Snail controls epithelial–mesenchymal transitions (EMT) by repressing E-cadherin expression and other epithelial genes. However, the mechanisms involved in the regulation of Snail function are not fully understood. Here we show that lysyl-oxidase-like 2 and 3 (LOXL2 and LOXL3), two members of the lysyl-oxidase gene family, interact and cooperate with Snail to downregulate E-cadherin expression. Snail's lysine residues 98 and 137 are essential for Snail stability, functional cooperation with LOXL2/3 and induction of EMT. Overexpression of LOXL2 or LOXL3 in epithelial cells induces an EMT process, supporting their implication in tumor progression. The biological importance of LOXL2 is further supported by RNA interference of LOXL2 in Snail-expressing metastatic carcinoma cells, which led to a strong decrease of tumor growth associated to increased apoptosis and reduced expression of mesenchymal and invasive/angiogenic markers. Taken together, these results establish a direct link between LOXL2 and Snail in carcinoma progression. | Descripción: | 13 páginas, 9 figuras.-- et al. | Versión del editor: | http://dx.doi.org/10.1038/sj.emboj.7600781 | URI: | http://hdl.handle.net/10261/32365 | DOI: | 10.1038/sj.emboj.7600781 | ISSN: | 0261-4189 |
Aparece en las colecciones: | (IN) Artículos (IIBM) Artículos (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
182
checked on 26-abr-2024
SCOPUSTM
Citations
388
checked on 12-may-2024
WEB OF SCIENCETM
Citations
370
checked on 29-feb-2024
Page view(s)
433
checked on 13-may-2024
Download(s)
122
checked on 13-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.