English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/32365
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

A molecular role for lysyl oxidase-like 2 enzyme in Snail regulation and tumor progression

AuthorsPeinado, Héctor; Iglesias de la Cruz, Carmen; Olmeda, David; Vega, Sonia; Nieto, M. Ángela ; Cano, Amparo ; Portillo, Francisco
KeywordsE-cadherin
EMT
LOXL
Snail
Tumor progression
Issue Date2005
PublisherNature Publishing Group
CitationEmbo Journal 24(19): 3446-3458 (2005)
AbstractThe transcription factor Snail controls epithelial–mesenchymal transitions (EMT) by repressing E-cadherin expression and other epithelial genes. However, the mechanisms involved in the regulation of Snail function are not fully understood. Here we show that lysyl-oxidase-like 2 and 3 (LOXL2 and LOXL3), two members of the lysyl-oxidase gene family, interact and cooperate with Snail to downregulate E-cadherin expression. Snail's lysine residues 98 and 137 are essential for Snail stability, functional cooperation with LOXL2/3 and induction of EMT. Overexpression of LOXL2 or LOXL3 in epithelial cells induces an EMT process, supporting their implication in tumor progression. The biological importance of LOXL2 is further supported by RNA interference of LOXL2 in Snail-expressing metastatic carcinoma cells, which led to a strong decrease of tumor growth associated to increased apoptosis and reduced expression of mesenchymal and invasive/angiogenic markers. Taken together, these results establish a direct link between LOXL2 and Snail in carcinoma progression.
Description13 páginas, 9 figuras.-- et al.
Publisher version (URL)http://dx.doi.org/10.1038/sj.emboj.7600781
URIhttp://hdl.handle.net/10261/32365
DOI10.1038/sj.emboj.7600781
ISSN0261-4189
Appears in Collections:(IN) Artículos
(IIBM) Artículos
(IC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.