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dc.contributor.authorPeinado, Héctor-
dc.contributor.authorIglesias de la Cruz, Carmen-
dc.contributor.authorOlmeda, David-
dc.contributor.authorVega, Sonia-
dc.contributor.authorNieto, M. Ángela-
dc.contributor.authorCano, Amparo-
dc.contributor.authorPortillo, Francisco-
dc.date.accessioned2011-02-15T11:19:50Z-
dc.date.available2011-02-15T11:19:50Z-
dc.date.issued2005-
dc.identifier.citationEmbo Journal 24(19): 3446-3458 (2005)es_ES
dc.identifier.issn0261-4189-
dc.identifier.urihttp://hdl.handle.net/10261/32365-
dc.description13 páginas, 9 figuras.-- et al.es_ES
dc.description.abstractThe transcription factor Snail controls epithelial–mesenchymal transitions (EMT) by repressing E-cadherin expression and other epithelial genes. However, the mechanisms involved in the regulation of Snail function are not fully understood. Here we show that lysyl-oxidase-like 2 and 3 (LOXL2 and LOXL3), two members of the lysyl-oxidase gene family, interact and cooperate with Snail to downregulate E-cadherin expression. Snail's lysine residues 98 and 137 are essential for Snail stability, functional cooperation with LOXL2/3 and induction of EMT. Overexpression of LOXL2 or LOXL3 in epithelial cells induces an EMT process, supporting their implication in tumor progression. The biological importance of LOXL2 is further supported by RNA interference of LOXL2 in Snail-expressing metastatic carcinoma cells, which led to a strong decrease of tumor growth associated to increased apoptosis and reduced expression of mesenchymal and invasive/angiogenic markers. Taken together, these results establish a direct link between LOXL2 and Snail in carcinoma progression.es_ES
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Education and Science (SAF01-02819 and SAF04-00361 to AC and BMC2002-0383 to MAN) and Instituto de Salud Carlos III, RTICCC (FIS03 C03/10) to AC and FP. HP was supported by a grant from Justesa Imagen, SA.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsclosedAccesses_ES
dc.subjectE-cadherines_ES
dc.subjectEMTes_ES
dc.subjectLOXLes_ES
dc.subjectSnailes_ES
dc.subjectTumor progressiones_ES
dc.titleA molecular role for lysyl oxidase-like 2 enzyme in Snail regulation and tumor progressiones_ES
dc.typeartículoes_ES
dc.identifier.doi10.1038/sj.emboj.7600781-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1038/sj.emboj.7600781es_ES
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