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Título: | Effect of Vitamin D on Graft-versus-Host Disease |
Autor: | Rodríguez-Gil, Alfonso CSIC; Carrillo Cruz, Estrella; Marrero-Cepeda, Cristina; Rodríguez, Guillermo; Pérez-Simón, José A. CSIC ORCID | Palabras clave: | Vitamin D receptor (VDR) Calcifediol Calcitriol Graft-versus-host disease Vitamin D |
Fecha de publicación: | 24-abr-2022 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Biomedicines 10(5): 987 (2022) | Resumen: | The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem-cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates. | Descripción: | This article belongs to the Special Issue Novel Prophylactic and Therapeutic Strategies for Acute Graft versus Host Disease. | Versión del editor: | https://doi.org/10.3390/biomedicines10050987 | URI: | http://hdl.handle.net/10261/306653 | DOI: | 10.3390/biomedicines10050987 | E-ISSN: | 2227-9059 |
Aparece en las colecciones: | (IBIS) Artículos |
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Graft-versus-Host-Disease.pdf | 1,48 MB | Adobe PDF | Visualizar/Abrir |
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