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http://hdl.handle.net/10261/306653
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Rodríguez-Gil, Alfonso | es_ES |
dc.contributor.author | Carrillo Cruz, Estrella | es_ES |
dc.contributor.author | Marrero-Cepeda, Cristina | es_ES |
dc.contributor.author | Rodríguez, Guillermo | es_ES |
dc.contributor.author | Pérez-Simón, José A. | es_ES |
dc.date.accessioned | 2023-04-18T22:20:28Z | - |
dc.date.available | 2023-04-18T22:20:28Z | - |
dc.date.issued | 2022-04-24 | - |
dc.identifier.citation | Biomedicines 10(5): 987 (2022) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/306653 | - |
dc.description | This article belongs to the Special Issue Novel Prophylactic and Therapeutic Strategies for Acute Graft versus Host Disease. | es_ES |
dc.description.abstract | The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem-cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates. | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Vitamin D receptor (VDR) | es_ES |
dc.subject | Calcifediol | es_ES |
dc.subject | Calcitriol | es_ES |
dc.subject | Graft-versus-host disease | es_ES |
dc.subject | Vitamin D | es_ES |
dc.title | Effect of Vitamin D on Graft-versus-Host Disease | es_ES |
dc.type | artículo de revisión | es_ES |
dc.identifier.doi | 10.3390/biomedicines10050987 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/biomedicines10050987 | es_ES |
dc.identifier.e-issn | 2227-9059 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.pmid | 35625724 | - |
dc.identifier.scopus | 2-s2.0-85129667422 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85129667422 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_dcae04bc | es_ES |
item.openairetype | artículo de revisión | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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Graft-versus-Host-Disease.pdf | 1,48 MB | Adobe PDF | Visualizar/Abrir |
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