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Título: | The combined action of omega-3 polyunsaturated fatty acids and grape proanthocyanidins on a rat model of diet-induced metabolic alterations |
Autor: | Ramos-Romero, Sara CSIC ORCID; Molinar-Toribio, Eunice; Pérez-Jiménez, Jara CSIC ORCID; Taltavull, Núria; Dasilva, Gabriel CSIC ORCID; Romeu, Marta; Medina, Isabel CSIC ORCID ; Torres, Josep Lluís CSIC ORCID | Fecha de publicación: | 2016 | Editor: | Royal Society of Chemistry (UK) | Citación: | Food and Function 7(8): 3516-3523 (2016) | Resumen: | It has been suggested that food components such as ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and (poly)phenols counteract diet-induced metabolic alterations by common or complementary mechanisms. To examine the effects of a combination of ω-3 PUFAs and (poly)phenols on such alterations, adult Wistar-Kyoto rats were fed an obesogenic high-fat high-sucrose diet supplemented, or not, for 24 weeks with: eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) 1 : 1 (16.6 g kg(-1) feed); proanthocyanidin-rich grape seed extract (GSE, 0.8 g kg(-1) feed); or EPA/DHA 1 : 1 + GSE. Body weight, feed intake, and plasma glucose were evaluated every 6 weeks, while adipose tissue weight, insulin, glucagon, ghrelin, leptin, adiponectin, cholesterol, and triglycerides were evaluated at the end of the experiment. ω-3 PUFAs reduced plasma leptin and cholesterol levels, but did not modify diet-induced perigonadal fat or plasma insulin levels; while GSE increased plasma triglyceride levels. The combined action of ω-3 PUFAs and the proanthocyanidins reduced plasma insulin and leptin, as well as partially prevented perigonadal fat accumulation. While separate supplementation with ω-3 PUFAs or grape proanthocyanidins may not counteract all the key metabolic changes induced by a high-energy-dense diet, the combination of both supplements reverts altered insulin, leptin and triglyceride levels to normal. | Descripción: | 8 pages, 3 figures | Versión del editor: | http://dx.doi.org/10.1039/c6fo00679e | URI: | http://hdl.handle.net/10261/305736 | DOI: | 10.1039/c6fo00679e | ISSN: | 2042-6496 | E-ISSN: | 2042-650X |
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