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Título: | Fitness alteration of foot-and-mouth disease virus mutants Measurement of adaptability of viral quasispecies |
Autor: | Martínez, Miguel Ángel; Carrillo García, Mª Cristina; González-Candelas, Fernando CSIC ORCID; Moya, A.; Domingo, Esteban CSIC ORCID; Sobrino Castelló, Francisco CSIC ORCID | Fecha de publicación: | 1991 | Editor: | American Society for Microbiology | Citación: | Journal of Virology 65(7): 3954-3957 (1991) | Resumen: | We document the rapid alteration of fitness of two foot-and-mouth disease virus (FMDV) mutants resistant to a neutralizing monoclonal antibody. Both mutants showed a selective disadvantage in BHK-21 cells when passaged in competition with their parental FMDV. Upon repeated replication of the mutants alone, they acquired a selective advantage over the parental FMDV and fixed additional genomic substitutions without reversion of the monoclonal antibody-resistant phenotype. Thus, variants that were previously kept at low frequency in the mutant spectrum of a viral quasispecies rapidly became the master sequence of a new genomic distribution and dominated the viral population. | URI: | http://hdl.handle.net/10261/293777 | ISSN: | 0022-538X | E-ISSN: | 1098-5514 |
Aparece en las colecciones: | (INIA) Artículos |
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