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Título: | Detection of QTL affecting fatty acid composition in the pig |
Autor: | Clop, Alex CSIC ORCID; Óvilo Martín, Cristina; Pérez-Enciso, Miguel CSIC ORCID; Cercos, A.; Tomàs, Anna; Fernández, Almudena; Coll, A.; Folch, Josep María CSIC ORCID; Barragán, Carmen; Díaz, Isabel; Oliver, M. A.; Varona, Luis; Silió, Luis; Sánchez, Armand CSIC ORCID; Noguera, José L. | Fecha de publicación: | 2003 | Editor: | Springer Nature | Citación: | Mammalian Genome 14: 650-656 (2003) | Resumen: | We present a QTL genome scan for fatty acid composition in pigs. An F 2 cross between Iberian x Landrace pigs and a regression approach fitting the carcass weight as a covariate for QTL identification was used. Chromosomes (Chrs) 4, 6, 8, 10, and 12 showed highly significant effects. The Chr 4 QTL influenced the linoleic content and both the fatty acid double-bond index and peroxidability index. In Chr 6 we found significant associations with the double-bond index and the unsaturated index of fatty acids. Chr 8 showed clear effects on the percentages of palmitic and palmitoleic fatty acids as well as the average chain length of fatty acids. In Chr 10 we detected a significant QTL for the percentage of myristic fatty acid, with an F value that was slightly above the genomewide threshold. The percentage of linolenic fatty acid was affected by a region on Chr 12. A nearly significant QTL for the content of gadoleic fatty acid was also detected in Chr 12. We also analyzed the genomic QTL distribution by a regression model that fits the backfat thickness as a covariate. Some of the QTL that were detected in our analysis could not be detected when the data were corrected by backfat thickness. This work shows how critical the selection of a covariate can be in the interpretation of results. This is the first report of a genome scan detection of QTL directly affecting fatty acid composition in pigs. | URI: | http://hdl.handle.net/10261/291015 | DOI: | 10.1007/s00335-002-2210-7 | ISSN: | 0938-8990 | E-ISSN: | 1432-1777 |
Aparece en las colecciones: | (INIA) Artículos |
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