Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/290445
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Interferon α/β receptor knockout mice as a model to study bluetongue virus infection |
Autor: | Ortego, Javier; de la Poza, F.; Marín-López, A. | Palabras clave: | IFNAR(−/−) mice Orbiviruses Bluetongue virus |
Fecha de publicación: | 2014 | Editor: | Elsevier | Citación: | Virus Research 182: 35-42 (2014) | Resumen: | Bluetongue is an arthropod-borne disease caused by a virus of the genus Orbivirus, the bluetongue virus (BTV), which affects ruminant livestock such as cattle, sheep, and goats and wild ruminants such as deer, and camelids. Recently, adult mice with gene knockouts of the interferon α/β receptor (IFNAR-/-) have been described as a model of lethal BTV infection. IFNAR(-/-) mice are highly susceptible to BTV-1, BTV-4 and BTV-8 infection when the virus is administered intravenously or subcutaneosuly. Disease progression and pathogenesis closely mimics signs of bluetongue disease in ruminants. In the present paper we review the studies where IFNAR(-/-) mice have been used as an animal model to study BTV transmission, pathogenesis, virulence, and protective efficacy of inactivated and new recombinant marker BTV vaccines. Furthermore, we report new data on protective efficacy of different strategies of BTV vaccination and also on induction of interferon α/β and proinflammatory immune responses in IFNAR(-/-) mice infected with BTV. © 2013 Elsevier B.V. | URI: | http://hdl.handle.net/10261/290445 | DOI: | 10.1016/j.virusres.2013.09.038 | ISSN: | 0168-1702 | E-ISSN: | 1872-7492 |
Aparece en las colecciones: | (INIA) Artículos |
Mostrar el registro completo
CORE Recommender
SCOPUSTM
Citations
19
checked on 29-abr-2024
WEB OF SCIENCETM
Citations
15
checked on 24-feb-2024
Page view(s)
23
checked on 30-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.