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Título: | Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues |
Autor: | Escalona, Z.; Álvarez, Belén; Uenishi, H.; Toki, D.; Yuste, Miriam CSIC; Revilla Calvo, Concepción; del Moral, M.; Alonso, Fernando; Ezquerra Martínez, Ángel; Domínguez, Javier | Palabras clave: | Siglec-10 B cells Monoclonal antibody Swine |
Fecha de publicación: | 2015 | Editor: | Elsevier | Citación: | Developmental and Comparative Immunology 48(1): 116-123 (2015) | Resumen: | Siglecs are sialic acid binding Ig-like proteins involved in the control of leukocyte responses. In this study we describe the characterization of a porcine orthologue of Siglec-10. A cDNA clone was obtained from a porcine library which encodes a protein with sequence homology to human Siglec-10. This cDNA codes for a type I transmembrane protein containing four Ig-like domains, a transmembrane region, and a cytoplasmic tail with three tyrosine-based motifs, including a membrane-proximal Grb2-binding motif, and two ITIM motifs. When expressed on transfected cells, porcine Siglec-10 was able to bind red blood cells in a sialic acid-dependent manner. Monoclonal antibodies were developed against this protein and used to examine its cell and tissue distribution in the pig. Siglec-10 was found to be expressed on blood B cells and B cell areas of the spleen and lymph nodes. A weak expression was also detected on monocytes. © 2014 Elsevier Ltd. | URI: | http://hdl.handle.net/10261/289742 | DOI: | 10.1016/j.dci.2014.09.011 | ISSN: | 0145-305X |
Aparece en las colecciones: | (INIA) Artículos |
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