Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/288716
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Mitochondrial oxidative stress induces cardiac fibrosis in obese rats through modulation of transthyretin |
Autor: | Martínez-Martínez, Ernesto; Fernández-Irigoyen, Joaquín; Santamaría, Enrique; Nieto, María Luisa CSIC ORCID; Bravo-San-Pedro, José Manuel; Cachofeiro, Victoria | Palabras clave: | Endoplasmic reticulum stress Fibrosis Mitochondrial oxidative stress Obesity Transthyretin |
Fecha de publicación: | 2022 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Sciences 23(15): 8080 (2022) | Resumen: | A proteomic approach was used to characterize potential mediators involved in the improvement in cardiac fibrosis observed with the administration of the mitochondrial antioxidant MitoQ in obese rats. Male Wistar rats were fed a standard diet (3.5% fat; CT) or a high-fat diet (35% fat; HFD) and treated with vehicle or MitoQ (200 μM) in drinking water for 7 weeks. Obesity modulated the expression of 33 proteins as compared with controls of the more than 1000 proteins identified. These include proteins related to endoplasmic reticulum (ER) stress and oxidative stress. Proteomic analyses revealed that HFD animals presented with an increase in cardiac transthyretin (TTR) protein levels, an effect that was prevented by MitoQ treatment in obese animals. This was confirmed by plasma levels, which were associated with those of cardiac levels of both binding immunoglobulin protein (BiP), a marker of ER stress, and fibrosis. TTR stimulated collagen I production and BiP in cardiac fibroblasts. This upregulation was prevented by the presence of MitoQ. In summary, the results suggest a role of TTR in cardiac fibrosis development associated with obesity and the beneficial effects of treatment with mitochondrial antioxidants. | Versión del editor: | http://dx.doi.org/10.3390/ijms23158080 | URI: | http://hdl.handle.net/10261/288716 | DOI: | 10.3390/ijms23158080 | Identificadores: | doi: 10.3390/ijms23158080 issn: 1661-6596 e-issn: 1422-0067 |
Aparece en las colecciones: | (IBGM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Mitochondrial Oxidative Stress_Martinez_PV_Art2022.pdf | 2,57 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
3
checked on 29-abr-2024
WEB OF SCIENCETM
Citations
1
checked on 27-feb-2024
Page view(s)
34
checked on 01-may-2024
Download(s)
82
checked on 01-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons