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http://hdl.handle.net/10261/285391
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Serna, Núria | - |
dc.contributor.author | Salinas Pena, Mónica | - |
dc.contributor.author | Mugianesi, F. | - |
dc.contributor.author | Dily, François Le | - |
dc.contributor.author | Marti-Renom, Marc A. | - |
dc.contributor.author | Jordan, Albert | - |
dc.date.accessioned | 2022-12-21T11:00:03Z | - |
dc.date.available | 2022-12-21T11:00:03Z | - |
dc.date.issued | 2022-04-02 | - |
dc.identifier | doi: 10.1093/nar/gkac226 | - |
dc.identifier | issn: 0305-1048 | - |
dc.identifier | e-issn: 1362-4962 | - |
dc.identifier.citation | Nucleic Acids Research 50(7): 3892-3910 (2022) | - |
dc.identifier.uri | http://hdl.handle.net/10261/285391 | - |
dc.description.abstract | Up to seven members of the histone H1 family may contribute to chromatin compaction and its regulation in human somatic cells. In breast cancer cells, knock-down of multiple H1 variants deregulates many genes, promotes the appearance of genome-wide accessibility sites and triggers an interferon response via activation of heterochromatic repeats. However, how these changes in the expression profile relate to the re-distribution of H1 variants as well as to genome conformational changes have not been yet studied. Here, we combined ChIP-seq of five endogenous H1 variants with Chromosome Conformation Capture analysis in wild-type and H1.2/H1.4 knock-down T47D cells. The results indicate that H1 variants coexist in the genome in two large groups depending on the local GC content and that their distribution is robust with respect to H1 depletion. Despite the small changes in H1 variants distribution, knock-down of H1 translated into more isolated but de-compacted chromatin structures at the scale of topologically associating domains (TADs). Such changes in TAD structure correlated with a coordinated gene expression response of their resident genes. This is the first report describing simultaneous profiling of five endogenous H1 variants and giving functional evidence of genome topology alterations upon H1 depletion in human cancer cells | - |
dc.description.sponsorship | Spanish Ministry of Science and Innovation [BFU2017-82805-C2-1-P and PID2020-112783GB-C21 to A.J., BFU2017-85926-P and PID2020-115696RB-I00 to M.A.M.-R. (AEI/FEDER, EU)]; European Union’s Seventh Framework Programme the ERC [609989 to M.A.M.-R., in part]; European Union’s Horizon 2020 research and innovation programme [676556 to M.A.M.-R.]; Generalitat de Catalunya Suport Grups de Recerca [AGAUR 2017-SGR-597 to A.J. and 2017-SGR-468 to M.A.M.-R.]; C.R.G. acknowledges support from ‘Centro de Excelencia Severo Ochoa 2013–2017’; SEV-2012-0208; CERCA Programme/Generalitat de Catalunya as well as support of the Spanish Ministry of Science and Innovation through the Instituto de Salud Carlos III; Generalitat de Catalunya through Departament de Salut and Departament d’Empresa i Coneixement; Spanish Ministry of Science and Innovation with funds from the European Regional Development Fund (ERDF) corresponding to the 2014–2020 Smart Growth Operating Program. Funding for open access charge: Spanish Ministry of Science and Innovation. | - |
dc.format | application/pdf | - |
dc.language | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-82805-C2-1-P/ES/ESPECIFICIDAD FUNCIONAL DE LAS VARIANTES DE LA HISTONA H1 HUMANA/ | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-112783GB-C21/ES/ESPECIFICIDAD FUNCIONAL DE LAS VARIANTES DE LA HISTONA H1 HUMANA Y PAPEL EN CANCER/ | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-85926-P/ES/ANALISIS ESTRUCTURAL DE GENOMAS Y DOMINIOS GENOMICOS/ | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115696RB-I00/ES/GWAS SPECIFICOS DE TEJIDO PARA EL ESTUDIO DE LA PREDISPOCICION GENETICA AL CANCER (TAGWAS)/ | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/676556 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO//SEV-2012-0208/ES/-/ | - |
dc.relation.isversionof | Publisher's version | - |
dc.relation.isbasedon | Serna, Núria; Salinas Pena, Mónica; Mugianesi, F.; Dily, François Le; Marti-Renom, Marc A.; Jordan, Albert; 2022; Coordinated changes in gene expression, H1 variant distribution and genome 3D conformation in response to H1 depletion [Dataset]; Oxford University Press; http://dx.doi.org/10.1093/nar/gkac226 | - |
dc.rights | openAccess | - |
dc.title | Coordinated changes in gene expression, H1 variant distribution and genome 3D conformation in response to H1 depletion | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1093/nar/gkac226 | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1093/nar/gkac226 | - |
dc.date.updated | 2022-12-21T11:00:03Z | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | European Research Council | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Generalitat de Catalunya | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000781 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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